Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MJ_1401Putative ATP dependent RNA helicase; Similar to SP:P32639 PID:603413 percent identity: 29.62; identified by sequence similarity; putative; Belongs to the DEAD box helicase family. (808 aa)    
Predicted Functional Partners:
tyrS
tyrosyl-tRNA synthetase (trS); Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).
 
     0.728
MJ_1399
Alignment in; Identified by sequence similarity; putative; Belongs to the UPF0200 family.
 
     0.686
MJ_1198
Conserved hypothetical protein; Similar to GB:L77117 PID:1591827 percent identity: 100.00; identified by sequence similarity; putative.
  
    0.675
MJ_1400
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1400.
       0.628
MJ_0392
Conserved hypothetical protein; A site-2 regulated intramembrane protease (S2P) that cleaves type-2 transmembrane proteins within their membrane-spanning domains; its endogenous substrate is unknown. Regulated intramembrane proteolysis (RIP) occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. A membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, this enzyme), while cytoplasmic proteases finish degr [...]
       0.595
MJ_0558
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 41.96; identified by sequence similarity; putative.
 
     0.564
MJ_0841
Conserved hypothetical protein; Radical SAM methyltransferase that is responsible for the C(5)-methylation of 'Arg-274' of the methyl-coenzyme M reductase (MCR) subunit alpha McrA. This post-translational methylation, despite being not essential in vivo, plays a role for the stability and structural integrity of MCR.
  
     0.509
MJ_0708
Conserved hypothetical protein; Probable pre-rRNA processing protein involved in ribosome biogenesis; Belongs to the TSR3 family.
  
     0.482
MJ_1599
Hypothetical protein; Identified by GeneMark; putative; M. jannaschii predicted coding region MJ1599.
  
    0.470
arcS
Alignment in; Is responsible for the final step in the biosynthesis of archaeosine, a modified nucleoside present in the dihydrouridine loop (D-loop) of archaeal tRNA. Catalyzes the conversion of 7-cyano-7- deazaguanine (preQ0)-modified tRNA to archaeosine-tRNA, transforming a nitrile group to a formamidine group. Can use either glutamine, asparagine or ammonium as amino donor.
  
     0.465
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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