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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MJ_1411Glyceraldehyde-3-phosphate dehydrogenase, NADP-dependent (gapN); Involved in F420 biosynthesis through the oxidation of lactaldehyde to lactate. The substrate preference order is propionaldehyde > DL-lactaldehyde, DL-glyceraldehyde > crotonaldehyde > glycolaldehyde > acetaldehyde, acrolein > formaldehyde. No activity was observed towards methylglyoxal or glyceraldehyde-3-phosphate. Has a preference for NAD over NADP. (463 aa)    
Predicted Functional Partners:
fucA
Fuculose-1-phosphate aldolase (fucA); Involved in the biosynthesis of the coenzyme F420 which requires phospholactate produced via the aldol cleavage of L-fuculose 1-phosphate and the NAD(+)-dependent oxidation of (S)-lactaldehyde. Catalyzes the reversible cleavage of L-fuculose 1- phosphate (Fuc1P) to yield dihydroxyacetone phosphate (DHAP) and S- lactaldehyde (Ref.2,. FucA possesses a high specificity for the dihydroxyacetone phosphate (DHAP), but accepts a great variety of different aldehydes such as DL-glyceraldehyde and glycolaldehyde.
  
 
 0.924
argD
Acetylornithine aminotransferase (argD); Similar to GB:X78854 PID:580729 SP:P54752 percent identity: 46.37; identified by sequence similarity; putative; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
 
 
 0.797
tal
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily.
  
 
 0.795
MJ_1656
2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (hpcE); Similar to SP:P37352 GB:X75028 GB:Z37980 PID:402576 PID:757826 percent identity: 40.11; identified by sequence similarity; putative; Belongs to the FAH family.
 
 
 0.787
MJ_1412
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 37.85; identified by sequence similarity; putative; Belongs to the UPF0288 family.
  
    0.783
MJ_1450
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 37.27; identified by sequence similarity; putative.
  
  
 0.771
MJ_1156
Cell division control protein 48 (cdc48), AAA family; Similar to GB:X79560 SP:P46464 PID:517390 percent identity: 57.53; identified by sequence similarity; putative; Belongs to the AAA ATPase family. CDC48 subfamily.
   
 0.770
MJ_1536
Thioredoxin reductase (trxB); Similar to GB:U02197 GB:L43967 SP:P47348 PID:1045780 percent identity: 38.93; identified by sequence similarity; putative.
 
  
 0.770
sucD
succinyl-CoA synthetase, alpha subunit (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.761
MJ_0033
Succinate dehydrogenase, flavoprotein subunit (sdhA); Similar to GP:1524302 percent identity: 41.63; identified by sequence similarity; putative.
  
 
 0.752
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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