node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MJ_0908 | MJ_1441 | MJ_0908 | MJ_1441 | Cobalamin biosynthesis protein (cobN); Similar to GB:M62866 SP:P29929 PID:151154 percent identity: 37.24; identified by sequence similarity; putative; Belongs to the Mg-chelatase subunit H family. | Magnesium chelatase subunit (chlH); Similar to GB:Z68495 PID:1154627 percent identity: 35.26; identified by sequence similarity; putative; Belongs to the Mg-chelatase subunit H family. | 0.909 |
MJ_0908 | cbiA | MJ_0908 | MJ_1421 | Cobalamin biosynthesis protein (cobN); Similar to GB:M62866 SP:P29929 PID:151154 percent identity: 37.24; identified by sequence similarity; putative; Belongs to the Mg-chelatase subunit H family. | Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | 0.948 |
MJ_0908 | cbiC | MJ_0908 | MJ_0930 | Cobalamin biosynthesis protein (cobN); Similar to GB:M62866 SP:P29929 PID:151154 percent identity: 37.24; identified by sequence similarity; putative; Belongs to the Mg-chelatase subunit H family. | Cobalamin biosynthesis precorrin isomerase (cbiC); Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate. Belongs to the CobH/CbiC family. | 0.495 |
MJ_0908 | cbiE | MJ_0908 | MJ_1522 | Cobalamin biosynthesis protein (cobN); Similar to GB:M62866 SP:P29929 PID:151154 percent identity: 37.24; identified by sequence similarity; putative; Belongs to the Mg-chelatase subunit H family. | Cobalamin biosynthesis precorrin-6Y methylase (cbiE); Catalyzes the methylation of C-5 in cobalt-precorrin-7 to form cobalt-precorrin-8. | 0.628 |
MJ_0908 | cbiH | MJ_0908 | MJ_0813 | Cobalamin biosynthesis protein (cobN); Similar to GB:M62866 SP:P29929 PID:151154 percent identity: 37.24; identified by sequence similarity; putative; Belongs to the Mg-chelatase subunit H family. | Cobalamin biosynthesis precorrin-3 methylase (cbiH); Methyltransferase that likely catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV. May also convert cobalt-precorrin-3 to cobalt-precorrin-4 (By similarity). | 0.420 |
MJ_0908 | cbiL | MJ_0908 | MJ_0771 | Cobalamin biosynthesis protein (cobN); Similar to GB:M62866 SP:P29929 PID:151154 percent identity: 37.24; identified by sequence similarity; putative; Belongs to the Mg-chelatase subunit H family. | Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. | 0.480 |
MJ_0908 | cobD | MJ_0908 | MJ_1314 | Cobalamin biosynthesis protein (cobN); Similar to GB:M62866 SP:P29929 PID:151154 percent identity: 37.24; identified by sequence similarity; putative; Belongs to the Mg-chelatase subunit H family. | Cobalamin biosynthesis protein B (cbiB); Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.406 |
MJ_1441 | MJ_0908 | MJ_1441 | MJ_0908 | Magnesium chelatase subunit (chlH); Similar to GB:Z68495 PID:1154627 percent identity: 35.26; identified by sequence similarity; putative; Belongs to the Mg-chelatase subunit H family. | Cobalamin biosynthesis protein (cobN); Similar to GB:M62866 SP:P29929 PID:151154 percent identity: 37.24; identified by sequence similarity; putative; Belongs to the Mg-chelatase subunit H family. | 0.909 |
MJ_1441 | cbiA | MJ_1441 | MJ_1421 | Magnesium chelatase subunit (chlH); Similar to GB:Z68495 PID:1154627 percent identity: 35.26; identified by sequence similarity; putative; Belongs to the Mg-chelatase subunit H family. | Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | 0.945 |
MJ_1441 | cbiC | MJ_1441 | MJ_0930 | Magnesium chelatase subunit (chlH); Similar to GB:Z68495 PID:1154627 percent identity: 35.26; identified by sequence similarity; putative; Belongs to the Mg-chelatase subunit H family. | Cobalamin biosynthesis precorrin isomerase (cbiC); Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate. Belongs to the CobH/CbiC family. | 0.465 |
MJ_1441 | cbiE | MJ_1441 | MJ_1522 | Magnesium chelatase subunit (chlH); Similar to GB:Z68495 PID:1154627 percent identity: 35.26; identified by sequence similarity; putative; Belongs to the Mg-chelatase subunit H family. | Cobalamin biosynthesis precorrin-6Y methylase (cbiE); Catalyzes the methylation of C-5 in cobalt-precorrin-7 to form cobalt-precorrin-8. | 0.628 |
MJ_1441 | cbiL | MJ_1441 | MJ_0771 | Magnesium chelatase subunit (chlH); Similar to GB:Z68495 PID:1154627 percent identity: 35.26; identified by sequence similarity; putative; Belongs to the Mg-chelatase subunit H family. | Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. | 0.450 |
cbiA | MJ_0908 | MJ_1421 | MJ_0908 | Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | Cobalamin biosynthesis protein (cobN); Similar to GB:M62866 SP:P29929 PID:151154 percent identity: 37.24; identified by sequence similarity; putative; Belongs to the Mg-chelatase subunit H family. | 0.948 |
cbiA | MJ_1441 | MJ_1421 | MJ_1441 | Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | Magnesium chelatase subunit (chlH); Similar to GB:Z68495 PID:1154627 percent identity: 35.26; identified by sequence similarity; putative; Belongs to the Mg-chelatase subunit H family. | 0.945 |
cbiA | cbiC | MJ_1421 | MJ_0930 | Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | Cobalamin biosynthesis precorrin isomerase (cbiC); Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate. Belongs to the CobH/CbiC family. | 0.996 |
cbiA | cbiE | MJ_1421 | MJ_1522 | Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | Cobalamin biosynthesis precorrin-6Y methylase (cbiE); Catalyzes the methylation of C-5 in cobalt-precorrin-7 to form cobalt-precorrin-8. | 0.915 |
cbiA | cbiF | MJ_1421 | MJ_1578 | Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | Cobalamin biosynthesis precorrin-3 methylase (cbiF); Catalyzes the methylation of C-11 in cobalt-precorrin-4 to form cobalt-precorrin-5A. | 0.976 |
cbiA | cbiH | MJ_1421 | MJ_0813 | Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | Cobalamin biosynthesis precorrin-3 methylase (cbiH); Methyltransferase that likely catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV. May also convert cobalt-precorrin-3 to cobalt-precorrin-4 (By similarity). | 0.956 |
cbiA | cbiL | MJ_1421 | MJ_0771 | Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. | 0.985 |
cbiA | cbiT | MJ_1421 | MJ_0391 | Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | Cobalamin biosynthesis precorrin-8W decarboxylase (cbiT); Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. | 0.967 |