| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MJ_0826 | cbiH | MJ_0826 | MJ_0813 | Conserved hypothetical protein; Similar to GP:1786696 percent identity: 24.82; identified by sequence similarity; putative. | Cobalamin biosynthesis precorrin-3 methylase (cbiH); Methyltransferase that likely catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV. May also convert cobalt-precorrin-3 to cobalt-precorrin-4 (By similarity). | 0.484 |
| MJ_0826 | cbiJ | MJ_0826 | MJ_0552 | Conserved hypothetical protein; Similar to GP:1786696 percent identity: 24.82; identified by sequence similarity; putative. | Cobalamin biosynthesis protein (cbiJ); Catalyzes the reduction of the macrocycle of cobalt- precorrin-6A to cobalt-precorrin-6B. | 0.459 |
| MJ_0826 | cbiL | MJ_0826 | MJ_0771 | Conserved hypothetical protein; Similar to GP:1786696 percent identity: 24.82; identified by sequence similarity; putative. | Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. | 0.403 |
| MJ_0826 | cobQ | MJ_0826 | MJ_0484 | Conserved hypothetical protein; Similar to GP:1786696 percent identity: 24.82; identified by sequence similarity; putative. | Cobyric acid synthase (cbiP); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); Belongs to the CobB/CobQ family. CobQ subfamily. | 0.434 |
| MJ_0826 | cobS | MJ_0826 | MJ_1438 | Conserved hypothetical protein; Similar to GP:1786696 percent identity: 24.82; identified by sequence similarity; putative. | Cobalamin (5'-phosphate) synthase (cobS); Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.849 |
| MJ_1437 | cobS | MJ_1437 | MJ_1438 | L-2-haloalkanoic acid dehalogenase isolog; Catalyzes the dephosphorylation of D,L-glyceraldehyde 3- phosphate in vitro; Belongs to the HAD-like hydrolase superfamily. | Cobalamin (5'-phosphate) synthase (cobS); Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.844 |
| MJ_1598 | cbiA | MJ_1598 | MJ_1421 | Conserved hypothetical protein; Similar to GP:1652098 percent identity: 35.67; identified by sequence similarity; putative; Belongs to the UPF0284 family. | Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | 0.806 |
| MJ_1598 | cbiH | MJ_1598 | MJ_0813 | Conserved hypothetical protein; Similar to GP:1652098 percent identity: 35.67; identified by sequence similarity; putative; Belongs to the UPF0284 family. | Cobalamin biosynthesis precorrin-3 methylase (cbiH); Methyltransferase that likely catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV. May also convert cobalt-precorrin-3 to cobalt-precorrin-4 (By similarity). | 0.522 |
| MJ_1598 | cbiJ | MJ_1598 | MJ_0552 | Conserved hypothetical protein; Similar to GP:1652098 percent identity: 35.67; identified by sequence similarity; putative; Belongs to the UPF0284 family. | Cobalamin biosynthesis protein (cbiJ); Catalyzes the reduction of the macrocycle of cobalt- precorrin-6A to cobalt-precorrin-6B. | 0.648 |
| MJ_1598 | cbiL | MJ_1598 | MJ_0771 | Conserved hypothetical protein; Similar to GP:1652098 percent identity: 35.67; identified by sequence similarity; putative; Belongs to the UPF0284 family. | Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. | 0.655 |
| MJ_1598 | cobD | MJ_1598 | MJ_1314 | Conserved hypothetical protein; Similar to GP:1652098 percent identity: 35.67; identified by sequence similarity; putative; Belongs to the UPF0284 family. | Cobalamin biosynthesis protein B (cbiB); Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.738 |
| MJ_1598 | cobQ | MJ_1598 | MJ_0484 | Conserved hypothetical protein; Similar to GP:1652098 percent identity: 35.67; identified by sequence similarity; putative; Belongs to the UPF0284 family. | Cobyric acid synthase (cbiP); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); Belongs to the CobB/CobQ family. CobQ subfamily. | 0.829 |
| MJ_1598 | cobS | MJ_1598 | MJ_1438 | Conserved hypothetical protein; Similar to GP:1652098 percent identity: 35.67; identified by sequence similarity; putative; Belongs to the UPF0284 family. | Cobalamin (5'-phosphate) synthase (cobS); Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.942 |
| MJ_1598 | cobY | MJ_1598 | MJ_1117 | Conserved hypothetical protein; Similar to GP:1652098 percent identity: 35.67; identified by sequence similarity; putative; Belongs to the UPF0284 family. | Conserved hypothetical protein; Guanylyltransferase that catalyzes the synthesis of adenosylcobinamide-GDP (AdoCbi-GDP) from adenosylcobinamide-phosphate (AdoCbi-P) and GTP. Is involved in adenosylcobalamin biosynthesis. Binds one GTP per dimer. Cannot use other NTPs or GDP. Does not display AdoCbi kinase activity. Is also able to catalyze the condensation of 2- phospho-L-lactate (LP) with GTP in vitro to form PPi and (2S)-lactyl-2- diphospho-5'-guanosine (LPPG), but is much less efficient than CofC, the presumed enzyme catalyzing this reaction in vivo. | 0.864 |
| cbiA | MJ_1598 | MJ_1421 | MJ_1598 | Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | Conserved hypothetical protein; Similar to GP:1652098 percent identity: 35.67; identified by sequence similarity; putative; Belongs to the UPF0284 family. | 0.806 |
| cbiA | cbiH | MJ_1421 | MJ_0813 | Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | Cobalamin biosynthesis precorrin-3 methylase (cbiH); Methyltransferase that likely catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV. May also convert cobalt-precorrin-3 to cobalt-precorrin-4 (By similarity). | 0.931 |
| cbiA | cbiJ | MJ_1421 | MJ_0552 | Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | Cobalamin biosynthesis protein (cbiJ); Catalyzes the reduction of the macrocycle of cobalt- precorrin-6A to cobalt-precorrin-6B. | 0.864 |
| cbiA | cbiL | MJ_1421 | MJ_0771 | Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway. | 0.985 |
| cbiA | cobD | MJ_1421 | MJ_1314 | Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | Cobalamin biosynthesis protein B (cbiB); Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. | 0.879 |
| cbiA | cobQ | MJ_1421 | MJ_0484 | Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source. | Cobyric acid synthase (cbiP); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity); Belongs to the CobB/CobQ family. CobQ subfamily. | 0.987 |
