STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MJ_1505ATP dependent RNA helicase, putative; Similar to GB:Z47047 SP:P40562 PID:557851 PID:763347 percent identity: 31.59; identified by sequence similarity; putative. (778 aa)    
Predicted Functional Partners:
rpl1
LSU ribosomal protein L1P (rplA); Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.
    
 0.906
rpa
Replication factor A related protein; Probably plays an essential for replication of the chromosome, DNA recombination and repair (By similarity). Binds approximately 20 nucleotides.
 
 
 0.890
MJ_1554
Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 42.23; identified by sequence similarity; putative.
    
 0.873
rpl40e
LSU ribosomal protein L40E (CEP52); Similar to PIR:B48470 percent identity: 61.11; identified by sequence similarity; putative; Belongs to the eukaryotic ribosomal protein eL40 family.
  
 
  0.864
pol
DNA polymerase B1; Similar to GB:D29671 PID:473967 PID:1620911 percent identity: 46.87; identified by sequence similarity; putative; Belongs to the DNA polymerase type-B family.
 
 
 
 0.858
pcn
Proliferating-cell nuclear antigen (pol30); Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
  
 
 
 0.834
smc
Chromosome segretation protein (smc1); Required for chromosome condensation and partitioning. Belongs to the SMC family.
 
 
 0.807
wecB
Lipopolysaccharide biosynthesis protein (wbpI); Catalyzes the reversible epimerization at C-2 of UDP-N- acetylglucosamine (UDP-GlcNAc) to produce UDP-N-acetylmannosamine (UDP- ManNAc), the activated donor of ManNAc residues; Belongs to the UDP-N-acetylglucosamine 2-epimerase family.
       0.774
topA
DNA topoisomerase I (topA) {Bacillus subtilis; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken stra [...]
    
 
 0.759
radB
DNA repair protein REC; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange (By similarity).
   
 
 0.742
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.