STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MJ_15493-keto-acyl-CoA thiolase; Similar to GP:2190267 percent identity: 31.48; identified by sequence similarity; putative. (392 aa)    
Predicted Functional Partners:
MJ_1546
Putative beta-ketoacyl acyl-carrier-protein synthase (fabH); Similar to PID:1197357 percent identity: 64.20; identified by sequence similarity; putative; Belongs to the thiolase-like superfamily. UPF0219 family.
 
 0.999
MJ_1552
Conserved hypothetical protein; Similar to PID:1197355 percent identity: 48.44; identified by sequence similarity; putative.
 
 
 0.999
MJ_1545
Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 52.42; identified by sequence similarity; putative.
  
    0.946
aksA
2-isopropylmalate synthase (leuA); Catalyzes the condensation of alpha-ketoglutarate and acetyl- CoA to form trans-homoaconitate. Can also catalyze the condensation of alpha-ketoadipate with acetyl-CoA to form (R)-homo(2)citrate, and the condensation of alpha-ketopimelate with acetyl-CoA to form (R)- homo(3)citrate; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
 
 0.943
leuA
2-isopropylmalate synthase (leuA); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate).
  
 
 0.943
MJ_0590
Conserved hypothetical protein; Catalyzes the formation of acetate and ATP from acetyl-CoA by using ADP and phosphate. Can also use butyryl-CoA, but not phenylacetyl-CoA. Cannot catalyze the reverse reaction. In the N-terminal section; belongs to the acetate CoA ligase alpha subunit family.
  
 
 0.935
sucD
succinyl-CoA synthetase, alpha subunit (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 0.932
cdhE
acetyl-CoA decarbonylase/synthase, subunit gamma (cdhE); Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2).
     
 0.926
porA
Pyruvate ferredoxin oxidoreductase, subunit alpha (porA); Similar to PID:1197363 percent identity: 57.33; identified by sequence similarity; putative.
  
 
 0.920
korA
2-ketoglutarate ferredoxin oxidoreductase, subunit alpha (korA); Similar to GB:X64521 PID:43498 percent identity: 44.24; identified by sequence similarity; putative.
  
 
 0.920
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.