STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cbiFCobalamin biosynthesis precorrin-3 methylase (cbiF); Catalyzes the methylation of C-11 in cobalt-precorrin-4 to form cobalt-precorrin-5A. (259 aa)    
Predicted Functional Partners:
cbiH
Cobalamin biosynthesis precorrin-3 methylase (cbiH); Methyltransferase that likely catalyzes the ring contraction and methylation of C-17 in cobalt-factor III to form cobalt-factor IV. May also convert cobalt-precorrin-3 to cobalt-precorrin-4 (By similarity).
 
 0.999
cbiG
Cobalamin biosynthesis protein (cbiG); Catalyzes the hydrolysis of the ring A acetate delta-lactone of cobalt-precorrin-5A resulting in the loss of the C-20 carbon and its attached methyl group in the form of acetaldehyde.
 
 0.999
cbiC
Cobalamin biosynthesis precorrin isomerase (cbiC); Catalyzes the conversion of cobalt-precorrin-8 to cobyrinate. Belongs to the CobH/CbiC family.
 
  
 0.995
cbiL
Cobalamin biosynthesis precorrin-2 methyltransferase (cbiL); Methylates cobalt-precorrin-2 at the C-20 position to produce cobalt-precorrin-3A in the anaerobic cobalamin biosynthesis pathway.
 
  
0.990
cbiT
Cobalamin biosynthesis precorrin-8W decarboxylase (cbiT); Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7.
 
  
 0.989
cbiJ
Cobalamin biosynthesis protein (cbiJ); Catalyzes the reduction of the macrocycle of cobalt- precorrin-6A to cobalt-precorrin-6B.
 
  
 0.987
cbiA
Cobyrinic acid a,c-diamide synthase (cbiA); Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP- dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.
  
 0.976
hemD
Uroporphyrinogen III synthase (hemD); Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
    
 0.953
cbiD
Cobalamin biosynthesis protein (cbiD); Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
 
  
 0.947
hemC
Porphobilinogen deaminase (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
    
 0.947
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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