STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MJ_1594Phosphoserine phosphatase (serB); Similar to SP:P06862 GB:X03046 PID:42948 PID:537228 GB:U00096 percent identity: 39.80; identified by sequence similarity; putative. (211 aa)    
Predicted Functional Partners:
glyA
Serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. The use of tetrahydrofolate (THF or H4PteGlu) as the pteridine substrate is 450-fold less efficient than that of H4MPT. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-allo-threonine and L-threo- beta-phenylserine; Belongs to the SHMT family.
  
 0.964
trpB
Tryptophan synthase beta subunit (trpB); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 
 0.932
pssA
CDP-diacylglycerol--serine O-phosphatidyltransferase (pssA); Similar to GB:D38022 SP:P39823 PID:1065993 GB:AL009126 percent identity: 43.51; identified by sequence similarity; putative; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
    
 0.917
trpA
Tryptophan synthase alpha subunit (trpA); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
  
 
 0.915
hisB
Imidazoleglycerol-phosphate dehydrogenase/histidinol-phosphatase (hisB); Similar to SP:P06987 GB:X03416 PID:41696 PID:41711 GB:U00096 percent identity: 47.09; identified by sequence similarity; putative.
  
  
 0.913
hisF
Imidazoleglycerol-phosphate synthase, cyclase subunit (hisF); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity).
  
  
 0.904
purS
Conserved hypothetical protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer [...]
   
   0.889
hisH
Imidazole glycerol phosphate synthase, subunit H (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity).
  
  
 0.873
hisI
phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase (hisIE); Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
  
  
 0.871
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase (hisA1); Similar to SP:P10371 PID:41713 GB:U00096 PID:1736702 PID:1736711 percent identity: 32.64; identified by sequence similarity; putative.
  
  
 0.867
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
Server load: low (28%) [HD]