Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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glyASerine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. The use of tetrahydrofolate (THF or H4PteGlu) as the pteridine substrate is 450-fold less efficient than that of H4MPT. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. Thus, is able to catalyze the cleavage of L-allo-threonine and L-threo- beta-phenylserine; Belongs to the SHMT family. (429 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase (thyA); May catalyze the biosynthesis of dTMP using an unknown cosubstrate; Belongs to the thymidylate synthase family. Archaeal-type ThyA subfamily.
  
 
 0.979
MJ_1594
Phosphoserine phosphatase (serB); Similar to SP:P06862 GB:X03046 PID:42948 PID:537228 GB:U00096 percent identity: 39.80; identified by sequence similarity; putative.
  
 0.969
MJ_0636
Dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative.
 
 
 0.967
trpA
Tryptophan synthase alpha subunit (trpA); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
   
 0.946
trpB
Tryptophan synthase beta subunit (trpB); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
    
 0.941
purD
Phosphoribosylamine--glycine ligase (purD); Similar to GB:J02732 SP:P12039 PID:143374 GB:AL009126 percent identity: 33.73; identified by sequence similarity; putative.
  
 
 0.940
fae-hps
D-arabino 3-hexulose 6-phosphate formaldehyde lyase isolog; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin; In the C-terminal section; belongs to the HPS/KGPDC family. HPS subfamily.
 
  
 0.935
mer
N5,N10-methylene-tetrahydromethanopterin reductase (mer); Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family.
    
 0.918
mtd
N5,N10-methylene-tetrahydromethanopterin dehydrogenase (mtd); Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
     
 0.907
hmd
H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenease (hmd); Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
     
  0.900
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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