Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
smcChromosome segretation protein (smc1); Required for chromosome condensation and partitioning. Belongs to the SMC family. (1169 aa)    
Predicted Functional Partners:
MJ_1134
Conserved hypothetical protein; Similar to GB:L09228 SP:P35154 PID:410131 GB:AL009126 percent identity: 21.63; identified by sequence similarity; putative.
 
 
 0.971
MJ_0535
Acetylpolyamine aminohydrolase (aphA); Putative deacetylase.
   
 0.848
topA
DNA topoisomerase I (topA) {Bacillus subtilis; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken stra [...]
 
 
 0.845
MJ_1505
ATP dependent RNA helicase, putative; Similar to GB:Z47047 SP:P40562 PID:557851 PID:763347 percent identity: 31.59; identified by sequence similarity; putative.
 
 
 0.807
srp54
Signal recognition particle, subunit SRP54; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
 
 
 0.799
MJ_1642
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 37.76; identified by sequence similarity; putative; Belongs to the M.jannaschii MJ0150/MJ0739/MJ0745/MJ1460/MJ1642 family.
       0.774
MJ_0942
ATP-dependent DNA helicase DinG, putative (dinG); Similar to GP:1736447 percent identity: 30.88; identified by sequence similarity; putative.
 
 
 0.773
rnhB
Ribonuclease HII (rnhB); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
 
 
 0.755
MJ_1554
Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 42.23; identified by sequence similarity; putative.
    
 
 0.752
pol
DNA polymerase B1; Similar to GB:D29671 PID:473967 PID:1620911 percent identity: 46.87; identified by sequence similarity; putative; Belongs to the DNA polymerase type-B family.
  
 
 0.707
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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