Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
htpXHeat shock protein HtpX, possibly protease (htpX); Similar to GB:M58470 SP:P23894 PID:146412 GB:U00096 PID:1736470 percent identity: 34.96; identified by sequence similarity; putative; Belongs to the peptidase M48B family. (284 aa)    
Predicted Functional Partners:
MJ_1458
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 58.60; identified by sequence similarity; putative.
  
    0.931
MJ_1681
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 46.61; identified by sequence similarity; putative.
       0.927
mdh
L-lactate dehydrogenase EGAD|7256|705; Catalyzes the reversible oxidation of (S)-malate and (S)- sulfolactate to oxaloacetate and sulfopyruvate, respectively. Can use both NADH and NADPH, although activity is higher with NADPH. Oxidation of (S)-sulfolactate is observed only in the presence of NADP(+). Can also oxidize tartrate. Cannot reduce pyruvate, nor alpha-ketoglutarate. Belongs to the LDH/MDH superfamily.
  
 0.905
MJ_0969
Conserved hypothetical protein; Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway.
  
    0.896
alaS
alanyl-tRNA synthetase (alaS); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (By similarity). Also functions in trans to edit the amino acid moiety from incorrectly charged Ser-tRNA(Ala), and maybe also from Gly-tRNA(Ala).
  
  
 0.868
MJ_1031
Conserved hypothetical protein; Similar to GP:1788715 percent identity: 21.48; identified by sequence similarity; putative.
  
  
 0.867
tal
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily.
  
 
 0.838
ths
Thermosome (ths); Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity; Belongs to the TCP-1 chaperonin family.
  
 0.797
MJ_0636
Dihydrolipoamide dehydrogenase; Identified by sequence similarity; putative.
  
 
 0.778
ilvD
Dihydroxy-acid dehydratase (ilvD); Similar to GB:M90761 SP:Q02139 PID:149431 percent identity: 44.53; identified by sequence similarity; putative; Belongs to the IlvD/Edd family.
  
 
 0.767
Your Current Organism:
Methanocaldococcus jannaschii
NCBI taxonomy Id: 243232
Other names: M. jannaschii DSM 2661, Methanocaldococcus jannaschii DSM 2661, Methanocaldococcus jannaschii str. DSM 2661, Methanococcus jannaschii DSM 2661
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