| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MCA0600 | glmU | MCA0600 | MCA0014 | Conserved hypothetical protein; Identified by similarity to GP:4545243. | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | 0.914 |
| MCA2033 | galE-2 | MCA2033 | MCA2451 | Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family. | UDP-glucose 4-epimerase; Identified by similarity to SP:Q59083; match to protein family HMM PF01370; match to protein family HMM PF07993; match to protein family HMM TIGR01179; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | 0.937 |
| MCA2033 | galU | MCA2033 | MCA2203 | Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family. | UTP-glucose-1-phosphate uridylyltransferase; Identified by similarity to OMNI:NMB0638; match to protein family HMM PF00483; match to protein family HMM TIGR01099. | 0.921 |
| MCA2033 | glmM | MCA2033 | MCA1847 | Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family. | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.557 |
| MCA2033 | glmS | MCA2033 | MCA0015 | Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family. | Glucosamine--fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.925 |
| MCA2033 | glmU | MCA2033 | MCA0014 | Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family. | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | 0.879 |
| MCA2033 | murA | MCA2033 | MCA1965 | Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.823 |
| galE-2 | MCA2033 | MCA2451 | MCA2033 | UDP-glucose 4-epimerase; Identified by similarity to SP:Q59083; match to protein family HMM PF01370; match to protein family HMM PF07993; match to protein family HMM TIGR01179; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family. | 0.937 |
| galE-2 | galU | MCA2451 | MCA2203 | UDP-glucose 4-epimerase; Identified by similarity to SP:Q59083; match to protein family HMM PF01370; match to protein family HMM PF07993; match to protein family HMM TIGR01179; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | UTP-glucose-1-phosphate uridylyltransferase; Identified by similarity to OMNI:NMB0638; match to protein family HMM PF00483; match to protein family HMM TIGR01099. | 0.973 |
| galE-2 | glmU | MCA2451 | MCA0014 | UDP-glucose 4-epimerase; Identified by similarity to SP:Q59083; match to protein family HMM PF01370; match to protein family HMM PF07993; match to protein family HMM TIGR01179; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | 0.868 |
| galU | MCA2033 | MCA2203 | MCA2033 | UTP-glucose-1-phosphate uridylyltransferase; Identified by similarity to OMNI:NMB0638; match to protein family HMM PF00483; match to protein family HMM TIGR01099. | Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family. | 0.921 |
| galU | galE-2 | MCA2203 | MCA2451 | UTP-glucose-1-phosphate uridylyltransferase; Identified by similarity to OMNI:NMB0638; match to protein family HMM PF00483; match to protein family HMM TIGR01099. | UDP-glucose 4-epimerase; Identified by similarity to SP:Q59083; match to protein family HMM PF01370; match to protein family HMM PF07993; match to protein family HMM TIGR01179; Belongs to the NAD(P)-dependent epimerase/dehydratase family. | 0.973 |
| galU | glmU | MCA2203 | MCA0014 | UTP-glucose-1-phosphate uridylyltransferase; Identified by similarity to OMNI:NMB0638; match to protein family HMM PF00483; match to protein family HMM TIGR01099. | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | 0.880 |
| galU | murA | MCA2203 | MCA1965 | UTP-glucose-1-phosphate uridylyltransferase; Identified by similarity to OMNI:NMB0638; match to protein family HMM PF00483; match to protein family HMM TIGR01099. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.865 |
| glmM | MCA2033 | MCA1847 | MCA2033 | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family. | 0.557 |
| glmM | glmS | MCA1847 | MCA0015 | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | Glucosamine--fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.970 |
| glmM | glmU | MCA1847 | MCA0014 | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | 0.994 |
| glmM | murA | MCA1847 | MCA1965 | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.673 |
| glmM | murC | MCA1847 | MCA2428 | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.635 |
| glmM | murE | MCA1847 | MCA2433 | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. | 0.441 |
