STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemLGlutamate-1-semialdehyde-2,1-aminomutase; Identified by similarity to SP:P23893; match to protein family HMM PF00202; match to protein family HMM TIGR00713. (426 aa)    
Predicted Functional Partners:
hemB
Delta-aminolevulinic acid dehydratase; Identified by similarity to SP:Q59643; match to protein family HMM PF00490; Belongs to the ALAD family.
 
 
 0.992
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.989
MCA1883
Non-ribosomal peptide synthetase; Identified by match to protein family HMM PF00501; match to protein family HMM PF00550; match to protein family HMM PF00668; match to protein family HMM PF00975; match to protein family HMM TIGR01733; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.972
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.955
MCA2107
Putative nonribosomal peptide synthetase; Identified by similarity to GP:9715733; match to protein family HMM PF00501; match to protein family HMM PF00550; match to protein family HMM TIGR01733; match to protein family HMM TIGR02353; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.845
MCA0055
Identified by match to protein family HMM PF00597.
       0.798
cysG
Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme.
   
 0.759
MCA0629
Putative phosphomethylpyrimidine kinase; Identified by similarity to SP:P55882.
 
  
 0.755
fabD
Malonyl CoA-acyl carrier protein transacylase; Identified by similarity to SP:P25715; match to protein family HMM PF00698; match to protein family HMM TIGR00128.
    
 0.696
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
  
 0.695
Your Current Organism:
Methylococcus capsulatus
NCBI taxonomy Id: 243233
Other names: M. capsulatus str. Bath, Methylococcus capsulatus ATCC 33009, Methylococcus capsulatus Bath, Methylococcus capsulatus MC, Methylococcus capsulatus NCIB 11132, Methylococcus capsulatus str. Bath
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