Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MCA0105D-alanyl-D-alanine carboxypeptidase; Identified by similarity to SP:P08506; match to protein family HMM PF00144; match to protein family HMM PF00768; match to protein family HMM PF07943; Belongs to the peptidase S11 family. (392 aa)    
Predicted Functional Partners:
mrdA
Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily.
 
 
 0.991
ftsI
Penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum.
  
 
 0.933
MCA1672
Putative penicillin-binding protein; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits).
   
 
 0.924
mrcA
Penicillin-binding protein 1A; Identified by similarity to SP:P02918; match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074.
     
 0.923
MCA1576
Putative penicillin-binding protein; Identified by similarity to SP:P76577; match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM PF06832; match to protein family HMM TIGR02073.
     
 0.901
MCA0107
Conserved hypothetical protein; Identified by similarity to GP:17427335; match to protein family HMM PF04359; Belongs to the UPF0250 family.
  
    0.760
MCA0106
Putative D-amino acid aminotransferase; Identified by similarity to SP:P54692; match to protein family HMM PF01063.
       0.743
rodA
Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily.
 
   
 0.671
lipB
Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.
 
    0.621
mreC
Rod shape-determining protein MreC; Involved in formation and maintenance of cell shape.
 
  
 0.613
Your Current Organism:
Methylococcus capsulatus
NCBI taxonomy Id: 243233
Other names: M. capsulatus str. Bath, Methylococcus capsulatus ATCC 33009, Methylococcus capsulatus Bath, Methylococcus capsulatus MC, Methylococcus capsulatus NCIB 11132, Methylococcus capsulatus str. Bath
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.