node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MCA0073 | bioB | MCA0073 | MCA1125 | Putative pyruvate formate lyase-activating enzyme; Identified by similarity to OMNI:MT3225; match to protein family HMM PF04055. | Biotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.505 |
MCA0073 | lipA | MCA0073 | MCA0110 | Putative pyruvate formate lyase-activating enzyme; Identified by similarity to OMNI:MT3225; match to protein family HMM PF04055. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.603 |
MCA0073 | nrdA | MCA0073 | MCA1634 | Putative pyruvate formate lyase-activating enzyme; Identified by similarity to OMNI:MT3225; match to protein family HMM PF04055. | Ribonucleoside-diphosphate reductase, alpha subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.534 |
MCA0106 | MCA0107 | MCA0106 | MCA0107 | Putative D-amino acid aminotransferase; Identified by similarity to SP:P54692; match to protein family HMM PF01063. | Conserved hypothetical protein; Identified by similarity to GP:17427335; match to protein family HMM PF04359; Belongs to the UPF0250 family. | 0.815 |
MCA0106 | lipA | MCA0106 | MCA0110 | Putative D-amino acid aminotransferase; Identified by similarity to SP:P54692; match to protein family HMM PF01063. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.600 |
MCA0106 | lipB | MCA0106 | MCA0109 | Putative D-amino acid aminotransferase; Identified by similarity to SP:P54692; match to protein family HMM PF01063. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.634 |
MCA0106 | mgtE | MCA0106 | MCA0108 | Putative D-amino acid aminotransferase; Identified by similarity to SP:P54692; match to protein family HMM PF01063. | Magnesium transporter; Acts as a magnesium transporter. | 0.537 |
MCA0107 | MCA0106 | MCA0107 | MCA0106 | Conserved hypothetical protein; Identified by similarity to GP:17427335; match to protein family HMM PF04359; Belongs to the UPF0250 family. | Putative D-amino acid aminotransferase; Identified by similarity to SP:P54692; match to protein family HMM PF01063. | 0.815 |
MCA0107 | lipA | MCA0107 | MCA0110 | Conserved hypothetical protein; Identified by similarity to GP:17427335; match to protein family HMM PF04359; Belongs to the UPF0250 family. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.672 |
MCA0107 | lipB | MCA0107 | MCA0109 | Conserved hypothetical protein; Identified by similarity to GP:17427335; match to protein family HMM PF04359; Belongs to the UPF0250 family. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.745 |
MCA0107 | mgtE | MCA0107 | MCA0108 | Conserved hypothetical protein; Identified by similarity to GP:17427335; match to protein family HMM PF04359; Belongs to the UPF0250 family. | Magnesium transporter; Acts as a magnesium transporter. | 0.532 |
aceF | gcvH | MCA3001 | MCA0051 | Pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.779 |
aceF | lipA | MCA3001 | MCA0110 | Pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.627 |
aceF | lipB | MCA3001 | MCA0109 | Pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.619 |
bioB | MCA0073 | MCA1125 | MCA0073 | Biotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Putative pyruvate formate lyase-activating enzyme; Identified by similarity to OMNI:MT3225; match to protein family HMM PF04055. | 0.505 |
bioB | lipA | MCA1125 | MCA0110 | Biotin synthetase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.825 |
gcvH | aceF | MCA0051 | MCA3001 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Pyruvate dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.779 |
gcvH | lipA | MCA0051 | MCA0110 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.867 |
gcvH | lipB | MCA0051 | MCA0109 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.838 |
gcvH | sucB | MCA0051 | MCA1953 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). | 0.779 |