Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hemNOxygen-independent coproporphyrinogen III oxidase; Identified by match to protein family HMM PF04055; match to protein family HMM PF06969; match to protein family HMM TIGR00538; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (465 aa)    
Predicted Functional Partners:
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 
 0.960
hemF
Coproporphyrinogen III oxidase, aerobic; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX.
 
  
 0.960
MCA1258
Conserved hypothetical protein TIGR00701; Identified by match to protein family HMM PF03653; match to protein family HMM TIGR00701.
 
  
 0.929
MCA0715
Hemerythrin family protein; Oxygen-binding protein. May be involved in a storage mechanism or for delivery to oxygen-requiring enzymes. The oxygen- binding site contains two iron atoms; Belongs to the hemerythrin family.
   
  
 0.698
MCA1812
Peptidase, U32 family; Identified by similarity to SP:P76403; match to protein family HMM PF01136.
  
    0.628
MCA0769
Pyruvate ferredoxin/flavodoxin oxidoreductase family protein; Identified by similarity to SP:P52647; match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM PF02775; match to protein family HMM TIGR02176.
     
 0.614
MCA2120
Transcriptional regulator, Crp/Fnr family; Identified by match to protein family HMM PF00027; match to protein family HMM PF00325.
 
  
 0.602
hoxW
HoxW protein; Identified by similarity to GP:1313919.
       0.584
MCA0114
NAD-reducing hydrogenase, beta subunit; Identified by similarity to SP:P22320; match to protein family HMM PF00374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
       0.584
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
  
 0.580
Your Current Organism:
Methylococcus capsulatus
NCBI taxonomy Id: 243233
Other names: M. capsulatus str. Bath, Methylococcus capsulatus ATCC 33009, Methylococcus capsulatus Bath, Methylococcus capsulatus MC, Methylococcus capsulatus NCIB 11132, Methylococcus capsulatus str. Bath
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.