node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MCA0811 | MCA1616 | MCA0811 | MCA1616 | Identified by match to protein family HMM PF01048. | C-5 cytosine-specific DNA methylase family protein; Identified by match to protein family HMM PF00145; match to protein family HMM TIGR00675. | 0.901 |
MCA0811 | ahcY | MCA0811 | MCA0138 | Identified by match to protein family HMM PF01048. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.919 |
MCA0811 | metH | MCA0811 | MCA1545 | Identified by match to protein family HMM PF01048. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.497 |
MCA0811 | metZ | MCA0811 | MCA2488 | Identified by match to protein family HMM PF01048. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.455 |
MCA1021 | ahcY | MCA1021 | MCA0138 | Aminotransferase, classes I and II; Identified by match to protein family HMM PF00155. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.900 |
MCA1021 | cysK | MCA1021 | MCA1022 | Aminotransferase, classes I and II; Identified by match to protein family HMM PF00155. | Cysteine synthase A; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.955 |
MCA1021 | hom | MCA1021 | MCA0597 | Aminotransferase, classes I and II; Identified by match to protein family HMM PF00155. | Homoserine dehydrogenase; Identified by similarity to SP:P29365; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | 0.809 |
MCA1021 | ilvA | MCA1021 | MCA0354 | Aminotransferase, classes I and II; Identified by match to protein family HMM PF00155. | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.810 |
MCA1021 | metE | MCA1021 | MCA2260 | Aminotransferase, classes I and II; Identified by match to protein family HMM PF00155. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.901 |
MCA1021 | metH | MCA1021 | MCA1545 | Aminotransferase, classes I and II; Identified by match to protein family HMM PF00155. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.931 |
MCA1021 | metZ | MCA1021 | MCA2488 | Aminotransferase, classes I and II; Identified by match to protein family HMM PF00155. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.959 |
MCA1616 | MCA0811 | MCA1616 | MCA0811 | C-5 cytosine-specific DNA methylase family protein; Identified by match to protein family HMM PF00145; match to protein family HMM TIGR00675. | Identified by match to protein family HMM PF01048. | 0.901 |
MCA1616 | ahcY | MCA1616 | MCA0138 | C-5 cytosine-specific DNA methylase family protein; Identified by match to protein family HMM PF00145; match to protein family HMM TIGR00675. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.905 |
MCA1616 | metK-1 | MCA1616 | MCA0139 | C-5 cytosine-specific DNA methylase family protein; Identified by match to protein family HMM PF00145; match to protein family HMM TIGR00675. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.914 |
ahcY | MCA0811 | MCA0138 | MCA0811 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Identified by match to protein family HMM PF01048. | 0.919 |
ahcY | MCA1021 | MCA0138 | MCA1021 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Aminotransferase, classes I and II; Identified by match to protein family HMM PF00155. | 0.900 |
ahcY | MCA1616 | MCA0138 | MCA1616 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | C-5 cytosine-specific DNA methylase family protein; Identified by match to protein family HMM PF00145; match to protein family HMM TIGR00675. | 0.905 |
ahcY | cysK | MCA0138 | MCA1022 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Cysteine synthase A; Identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.843 |
ahcY | hom | MCA0138 | MCA0597 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Homoserine dehydrogenase; Identified by similarity to SP:P29365; match to protein family HMM PF00742; match to protein family HMM PF01842; match to protein family HMM PF03447. | 0.815 |
ahcY | ilvA | MCA0138 | MCA0354 | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.832 |