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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
iscSCysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (403 aa)    
Predicted Functional Partners:
MCA0248
NifU family protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
 
 0.991
MCA2088
Conserved hypothetical protein; Identified by similarity to GP:17427822; match to protein family HMM PF01206; Belongs to the sulfur carrier protein TusA family.
   
 0.975
MCA2211
Identified by match to protein family HMM PF00899; match to protein family HMM PF05237.
   
 0.972
MCA0988
NifU family protein; Identified by similarity to SP:P77310; match to protein family HMM PF01592; match to protein family HMM TIGR01994.
  
 0.928
sseA
Mercaptopyruvate sulfurtransferase; Identified by similarity to GP:6009981; match to protein family HMM PF00581.
   
 0.913
nifS
Cysteine desulfurase; Identified by similarity to SP:Q43884; match to protein family HMM PF00266.
  
  
 
0.912
MCA2884
Cysteine desulfurase; Identified by similarity to SP:Q43884; match to protein family HMM PF00266.
  
  
 
0.912
hscB
Co-chaperone Hsc20; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.
 
 
 0.880
MCA0253
Ferredoxin, 2Fe-2S; Identified by similarity to SP:P25528; match to protein family HMM PF00111; match to protein family HMM TIGR02007.
 
 0.863
MCA0239
Putative nitrogen fixation protein nifQ; Identified by similarity to SP:P11068; match to protein family HMM PF04891.
  
 0.852
Your Current Organism:
Methylococcus capsulatus
NCBI taxonomy Id: 243233
Other names: M. capsulatus str. Bath, Methylococcus capsulatus ATCC 33009, Methylococcus capsulatus Bath, Methylococcus capsulatus MC, Methylococcus capsulatus NCIB 11132, Methylococcus capsulatus str. Bath
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