| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MCA0508 | gcvH | MCA0508 | MCA0051 | Methylenetetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase; Identified by similarity to SP:P55818. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.900 |
| MCA0508 | gcvPA | MCA0508 | MCA0349 | Methylenetetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase; Identified by similarity to SP:P55818. | Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.900 |
| MCA0508 | gcvPB | MCA0508 | MCA0348 | Methylenetetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase; Identified by similarity to SP:P55818. | Glycine cleavage system P protein, subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.900 |
| MCA0508 | gcvT | MCA0508 | MCA0350 | Methylenetetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase; Identified by similarity to SP:P55818. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.900 |
| MCA0508 | glyA | MCA0508 | MCA1660 | Methylenetetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase; Identified by similarity to SP:P55818. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.908 |
| MCA0508 | lpdA | MCA0508 | MCA3002 | Methylenetetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase; Identified by similarity to SP:P55818. | Pyruvate dehydrogenase complex, E3 component, dihydrolipoamide dehydrogenase; Identified by similarity to SP:P00391; match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992; match to protein family HMM TIGR01350. | 0.901 |
| MCA0508 | metF | MCA0508 | MCA0137 | Methylenetetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase; Identified by similarity to SP:P55818. | 5,10-methylenetetrahydrofolate reductase; Identified by similarity to SP:P00394; match to protein family HMM PF02219; match to protein family HMM TIGR00676; Belongs to the methylenetetrahydrofolate reductase family. | 0.900 |
| MCA0508 | thyA | MCA0508 | MCA2728 | Methylenetetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase; Identified by similarity to SP:P55818. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.900 |
| MCA2997 | gcvH | MCA2997 | MCA0051 | Aminotransferase, class I; Identified by match to protein family HMM PF00155. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.900 |
| MCA2997 | gcvPA | MCA2997 | MCA0349 | Aminotransferase, class I; Identified by match to protein family HMM PF00155. | Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.900 |
| MCA2997 | gcvPB | MCA2997 | MCA0348 | Aminotransferase, class I; Identified by match to protein family HMM PF00155. | Glycine cleavage system P protein, subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.902 |
| MCA2997 | gcvT | MCA2997 | MCA0350 | Aminotransferase, class I; Identified by match to protein family HMM PF00155. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.902 |
| MCA2997 | glyA | MCA2997 | MCA1660 | Aminotransferase, class I; Identified by match to protein family HMM PF00155. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.910 |
| MCA2997 | lpdA | MCA2997 | MCA3002 | Aminotransferase, class I; Identified by match to protein family HMM PF00155. | Pyruvate dehydrogenase complex, E3 component, dihydrolipoamide dehydrogenase; Identified by similarity to SP:P00391; match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992; match to protein family HMM TIGR01350. | 0.900 |
| MCA2997 | sgaA | MCA2997 | MCA1406 | Aminotransferase, class I; Identified by match to protein family HMM PF00155. | Serine--glyoxylate aminotransferase; Identified by similarity to SP:P55819; match to protein family HMM PF00266. | 0.909 |
| gcvH | MCA0508 | MCA0051 | MCA0508 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Methylenetetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase; Identified by similarity to SP:P55818. | 0.900 |
| gcvH | MCA2997 | MCA0051 | MCA2997 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Aminotransferase, class I; Identified by match to protein family HMM PF00155. | 0.900 |
| gcvH | gcvPA | MCA0051 | MCA0349 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system P protein, subunit 1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.998 |
| gcvH | gcvPB | MCA0051 | MCA0348 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system P protein, subunit 2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. | 0.999 |
| gcvH | gcvT | MCA0051 | MCA0350 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.999 |
