STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MCA0508Methylenetetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase; Identified by similarity to SP:P55818. (286 aa)    
Predicted Functional Partners:
MCA2778
Formaldehyde-activating enzyme domain protein; Identified by similarity to GP:11193064.
  
  
 0.993
MCA2866
Formaldehyde-activating enzyme; Identified by similarity to GP:11193064.
  
  
 0.993
mch
Putative n5,n10-methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT; Belongs to the MCH family.
 
  
 0.992
fchA
Methenyltetrahydrofolate cyclohydrolase; Identified by similarity to SP:Q49135; match to protein family HMM PF04961.
 
  
 0.979
MCA3018
Putative methylene tetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase; Identified by similarity to SP:P55818.
  
  
 
0.922
MCA3019
Putative methylene tetrahydromethanopterin dehydrogenase/methylenetetrahydrofolate dehydrogenase; Identified by similarity to SP:P55818.
  
  
 
0.920
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
  0.913
metF
5,10-methylenetetrahydrofolate reductase; Identified by similarity to SP:P00394; match to protein family HMM PF02219; match to protein family HMM TIGR00676; Belongs to the methylenetetrahydrofolate reductase family.
     
  0.900
gcvT
Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.
     
  0.900
purT
Phosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family.
     
  0.900
Your Current Organism:
Methylococcus capsulatus
NCBI taxonomy Id: 243233
Other names: M. capsulatus str. Bath, Methylococcus capsulatus ATCC 33009, Methylococcus capsulatus Bath, Methylococcus capsulatus MC, Methylococcus capsulatus NCIB 11132, Methylococcus capsulatus str. Bath
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