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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MCA0647Identified by match to protein family HMM PF07885. (247 aa)    
Predicted Functional Partners:
parE
DNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily.
    
 
 0.700
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
    
 
 0.700
MCA0120
Putative membrane protein; Identified by match to protein family HMM PF01594.
 
     0.692
MCA0408
Conserved hypothetical protein; Identified by similarity to OMNI:NTL01SS00205.
 
     0.655
MCA1827
Conserved hypothetical protein; Identified by similarity to GP:12698380.
  
     0.577
MCA1291
Conserved hypothetical protein; Identified by similarity to OMNI:NTL01SS03128.
  
     0.521
MCA0646
Hypothetical protein; Identified by Glimmer2; putative.
       0.507
MCA1204
Sensory box histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00785; match to protein family HMM PF00989; match to protein family HMM PF01590; match to protein family HMM PF01627; match to protein family HMM PF02518; match to protein family HMM TIGR00229.
  
 
 0.450
MCA1869
Conserved hypothetical protein; Identified by similarity to OMNI:NTL01SS00582; match to protein family HMM PF07883.
 
     0.437
MCA1744
Acetyltransferase, GNAT family; Identified by similarity to GP:1652538; match to protein family HMM PF00583.
  
     0.433
Your Current Organism:
Methylococcus capsulatus
NCBI taxonomy Id: 243233
Other names: M. capsulatus str. Bath, Methylococcus capsulatus ATCC 33009, Methylococcus capsulatus Bath, Methylococcus capsulatus MC, Methylococcus capsulatus NCIB 11132, Methylococcus capsulatus str. Bath
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