Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
sqsSqualene synthase; Identified by similarity to GP:3164081; match to protein family HMM PF00494. (362 aa)    
Predicted Functional Partners:
sqhC
Squalene-hopene cyclase; Identified by similarity to GP:3164082; match to protein family HMM PF00432; match to protein family HMM TIGR01507; match to protein family HMM TIGR01787.
  
 0.990
ispA
Geranyltranstransferase; Identified by similarity to SP:P45204; match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family.
 
 0.970
uppS
Undecaprenyl diphosphate synthase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
   
 
 0.926
MCA0811
Identified by match to protein family HMM PF01048.
 
   
 0.909
MCA2873
Squalene cyclase family protein; Identified by similarity to GP:1098635; match to protein family HMM PF00432; match to protein family HMM TIGR01787.
 
  
 0.906
ispB
Octaprenyl-diphosphate synthase; Identified by similarity to SP:P19641; match to protein family HMM PF00348; Belongs to the FPP/GGPP synthase family.
  
 0.899
MCA0810
Putative membrane protein; Identified by similarity to GP:3164083.
 
     0.881
nuoCD
NADH dehydrogenase I, C/D subunits; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family.
   
 0.840
cyp51
Cytochrome P450 51; Identified by similarity to SP:P77901; match to protein family HMM PF00067.
 
 
 
 0.824
gap
Glyceraldehyde 3-phosphate dehydrogenase; Identified by similarity to SP:P50321; match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.
  
  
 0.795
Your Current Organism:
Methylococcus capsulatus
NCBI taxonomy Id: 243233
Other names: M. capsulatus str. Bath, Methylococcus capsulatus ATCC 33009, Methylococcus capsulatus Bath, Methylococcus capsulatus MC, Methylococcus capsulatus NCIB 11132, Methylococcus capsulatus str. Bath
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