Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MCA0838Type I restriction-modification system, R subunit; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1210 aa)    
Predicted Functional Partners:
MCA0836
Type I restriction-modification system, S subunit, EcoA family; Identified by match to protein family HMM PF01420.
 
  
 0.967
hsdM
Type I restriction-modification system, M subunit; Identified by similarity to GP:17984614; match to protein family HMM PF02384; match to protein family HMM PF02506; match to protein family HMM TIGR00497.
 
  
 0.864
MCA0837
Conserved hypothetical protein; Identified by similarity to SP:P44014.
       0.821
MCA1890
Type I restriction-modification system, S subunit; Identified by match to protein family HMM PF01420.
 
  
 0.801
MCA0835
Fic family protein; Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins.
 
     0.695
uvrA
Excinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
     
 0.663
MCA0921
Conserved domain protein; Identified by similarity to GP:6959523.
  
  
 0.645
MCA0278
Type I restriction-modification system, M subunit; Identified by similarity to OMNI:NTL03PA02735; match to protein family HMM PF02384; match to protein family HMM PF02506.
 
  
 0.638
uvrB
Excinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
     
 0.636
MCA0269
Conserved domain protein; Identified by similarity to OMNI:NTL02SA0423.
 
  
 0.617
Your Current Organism:
Methylococcus capsulatus
NCBI taxonomy Id: 243233
Other names: M. capsulatus str. Bath, Methylococcus capsulatus ATCC 33009, Methylococcus capsulatus Bath, Methylococcus capsulatus MC, Methylococcus capsulatus NCIB 11132, Methylococcus capsulatus str. Bath
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