| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MCA1101 | MCA2130 | MCA1101 | MCA2130 | Identified by match to protein family HMM PF00394; match to protein family HMM PF07731; match to protein family HMM PF07732. | Conserved hypothetical protein; Identified by similarity to GP:3282847. | 0.618 |
| MCA1101 | MCA3044 | MCA1101 | MCA3044 | Identified by match to protein family HMM PF00394; match to protein family HMM PF07731; match to protein family HMM PF07732. | SIS domain protein; Identified by match to protein family HMM PF01380. | 0.618 |
| MCA1101 | arsC | MCA1101 | MCA2520 | Identified by match to protein family HMM PF00394; match to protein family HMM PF07731; match to protein family HMM PF07732. | Arsenate reductase; Identified by similarity to SP:P37311; match to protein family HMM PF03960; match to protein family HMM TIGR00014. | 0.631 |
| MCA1101 | cas2 | MCA1101 | MCA0650 | Identified by match to protein family HMM PF00394; match to protein family HMM PF07731; match to protein family HMM PF07732. | CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. | 0.618 |
| MCA1101 | hypA | MCA1101 | MCA1601 | Identified by match to protein family HMM PF00394; match to protein family HMM PF07731; match to protein family HMM PF07732. | Hydrogenase expression/formation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | 0.623 |
| MCA1101 | nuoA | MCA1101 | MCA1359 | Identified by match to protein family HMM PF00394; match to protein family HMM PF07731; match to protein family HMM PF07732. | NADH dehydrogenase I, A subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family. | 0.621 |
| MCA1101 | pmoB | MCA1101 | MCA1796 | Identified by match to protein family HMM PF00394; match to protein family HMM PF07731; match to protein family HMM PF07732. | Methane monooxygenase, B subunit; Methane monooxygenase is responsible for the initial oxygenation of methane to methanol in methanotrophs. At least in vitro, specific quinols can replace NADH as reductants. | 0.588 |
| MCA1101 | ppa | MCA1101 | MCA0112 | Identified by match to protein family HMM PF00394; match to protein family HMM PF07731; match to protein family HMM PF07732. | Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. | 0.618 |
| MCA1101 | tatB | MCA1101 | MCA1487 | Identified by match to protein family HMM PF00394; match to protein family HMM PF07731; match to protein family HMM PF07732. | Sec-independent protein translocase protein TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. | 0.750 |
| MCA1101 | tatC | MCA1101 | MCA1486 | Identified by match to protein family HMM PF00394; match to protein family HMM PF07731; match to protein family HMM PF07732. | Sec-independent protein translocase TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. | 0.752 |
| MCA2130 | MCA1101 | MCA2130 | MCA1101 | Conserved hypothetical protein; Identified by similarity to GP:3282847. | Identified by match to protein family HMM PF00394; match to protein family HMM PF07731; match to protein family HMM PF07732. | 0.618 |
| MCA2130 | MCA3044 | MCA2130 | MCA3044 | Conserved hypothetical protein; Identified by similarity to GP:3282847. | SIS domain protein; Identified by match to protein family HMM PF01380. | 0.618 |
| MCA2130 | arsC | MCA2130 | MCA2520 | Conserved hypothetical protein; Identified by similarity to GP:3282847. | Arsenate reductase; Identified by similarity to SP:P37311; match to protein family HMM PF03960; match to protein family HMM TIGR00014. | 0.618 |
| MCA2130 | cas2 | MCA2130 | MCA0650 | Conserved hypothetical protein; Identified by similarity to GP:3282847. | CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. | 0.618 |
| MCA2130 | hypA | MCA2130 | MCA1601 | Conserved hypothetical protein; Identified by similarity to GP:3282847. | Hydrogenase expression/formation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. | 0.618 |
| MCA2130 | nuoA | MCA2130 | MCA1359 | Conserved hypothetical protein; Identified by similarity to GP:3282847. | NADH dehydrogenase I, A subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family. | 0.618 |
| MCA2130 | pmoB | MCA2130 | MCA1796 | Conserved hypothetical protein; Identified by similarity to GP:3282847. | Methane monooxygenase, B subunit; Methane monooxygenase is responsible for the initial oxygenation of methane to methanol in methanotrophs. At least in vitro, specific quinols can replace NADH as reductants. | 0.626 |
| MCA2130 | ppa | MCA2130 | MCA0112 | Conserved hypothetical protein; Identified by similarity to GP:3282847. | Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions. | 0.618 |
| MCA3044 | MCA1101 | MCA3044 | MCA1101 | SIS domain protein; Identified by match to protein family HMM PF01380. | Identified by match to protein family HMM PF00394; match to protein family HMM PF07731; match to protein family HMM PF07732. | 0.618 |
| MCA3044 | MCA2130 | MCA3044 | MCA2130 | SIS domain protein; Identified by match to protein family HMM PF01380. | Conserved hypothetical protein; Identified by similarity to GP:3282847. | 0.618 |
