node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MCA0661 | MCA2033 | MCA0661 | MCA2033 | ROK family protein; Identified by similarity to SP:P75959; match to protein family HMM PF00480. | Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family. | 0.947 |
MCA0661 | pfp | MCA0661 | MCA1251 | ROK family protein; Identified by similarity to SP:P75959; match to protein family HMM PF00480. | Putative 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade [...] | 0.937 |
MCA0661 | pgi | MCA0661 | MCA1247 | ROK family protein; Identified by similarity to SP:P75959; match to protein family HMM PF00480. | Glucose-6-phosphate isomerase; Identified by similarity to SP:P11537; match to protein family HMM PF00342. | 0.938 |
MCA0661 | pyk | MCA0661 | MCA2597 | ROK family protein; Identified by similarity to SP:P75959; match to protein family HMM PF00480. | Pyruvate kinase; Identified by similarity to SP:P21599; match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. | 0.401 |
MCA2033 | MCA0661 | MCA2033 | MCA0661 | Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family. | ROK family protein; Identified by similarity to SP:P75959; match to protein family HMM PF00480. | 0.947 |
MCA2033 | pfp | MCA2033 | MCA1251 | Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family. | Putative 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade [...] | 0.927 |
MCA2033 | pgi | MCA2033 | MCA1247 | Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family. | Glucose-6-phosphate isomerase; Identified by similarity to SP:P11537; match to protein family HMM PF00342. | 0.951 |
MCA2738 | pfp | MCA2738 | MCA1251 | Putative hexulose-6-phosphate synthase/SIS domain protein; Identified by similarity to GP:6899861; match to protein family HMM PF00215; match to protein family HMM PF01380. | Putative 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade [...] | 0.935 |
MCA2738 | pgi | MCA2738 | MCA1247 | Putative hexulose-6-phosphate synthase/SIS domain protein; Identified by similarity to GP:6899861; match to protein family HMM PF00215; match to protein family HMM PF01380. | Glucose-6-phosphate isomerase; Identified by similarity to SP:P11537; match to protein family HMM PF00342. | 0.935 |
MCA2738 | tal | MCA2738 | MCA3045 | Putative hexulose-6-phosphate synthase/SIS domain protein; Identified by similarity to GP:6899861; match to protein family HMM PF00215; match to protein family HMM PF01380. | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | 0.457 |
MCA2738 | tkt-1 | MCA2738 | MCA3040 | Putative hexulose-6-phosphate synthase/SIS domain protein; Identified by similarity to GP:6899861; match to protein family HMM PF00215; match to protein family HMM PF01380. | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | 0.927 |
MCA2738 | tkt-2 | MCA2738 | MCA3046 | Putative hexulose-6-phosphate synthase/SIS domain protein; Identified by similarity to GP:6899861; match to protein family HMM PF00215; match to protein family HMM PF01380. | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | 0.927 |
fbaA-1 | pfp | MCA3041 | MCA1251 | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. | Putative 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade [...] | 0.955 |
fbaA-1 | pgi | MCA3041 | MCA1247 | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. | Glucose-6-phosphate isomerase; Identified by similarity to SP:P11537; match to protein family HMM PF00342. | 0.940 |
fbaA-1 | pyk | MCA3041 | MCA2597 | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. | Pyruvate kinase; Identified by similarity to SP:P21599; match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family. | 0.879 |
fbaA-1 | tal | MCA3041 | MCA3045 | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | 0.945 |
fbaA-1 | tkt-1 | MCA3041 | MCA3040 | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | 0.979 |
fbaA-1 | tkt-2 | MCA3041 | MCA3046 | Fructose-bisphosphate aldolase, class II; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. | Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. | 0.939 |
hppA-2 | pfp | MCA1252 | MCA1251 | V-type H(+)-translocating pyrophosphatase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. | Putative 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade [...] | 0.913 |
pfp | MCA0661 | MCA1251 | MCA0661 | Putative 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade [...] | ROK family protein; Identified by similarity to SP:P75959; match to protein family HMM PF00480. | 0.937 |