| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MCA1495 | MCA2202 | MCA1495 | MCA2202 | Conserved hypothetical protein; Identified by similarity to GP:2624947. | Aspartate aminotransferase; Identified by similarity to SP:P23034; match to protein family HMM PF00155. | 0.800 |
| MCA1495 | aroC | MCA1495 | MCA0702 | Conserved hypothetical protein; Identified by similarity to GP:2624947. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.902 |
| MCA1495 | hisC-1 | MCA1495 | MCA1113 | Conserved hypothetical protein; Identified by similarity to GP:2624947. | Histidinol-phosphate aminotransferase; Identified by similarity to SP:P45358; match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.800 |
| MCA1495 | hisC-2 | MCA1495 | MCA1417 | Conserved hypothetical protein; Identified by similarity to GP:2624947. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.800 |
| MCA1495 | pheA | MCA1495 | MCA1418 | Conserved hypothetical protein; Identified by similarity to GP:2624947. | Chorismate mutase/prephenate dehydratase; Identified by similarity to SP:P27603; match to protein family HMM PF00800; match to protein family HMM PF01817; match to protein family HMM PF01842; match to protein family HMM TIGR01807. | 0.912 |
| MCA1495 | trpE | MCA1495 | MCA2584 | Conserved hypothetical protein; Identified by similarity to GP:2624947. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.900 |
| MCA1495 | trpG | MCA1495 | MCA2585 | Conserved hypothetical protein; Identified by similarity to GP:2624947. | Anthranilate synthase component II; Identified by similarity to SP:P20576; match to protein family HMM PF00117; match to protein family HMM TIGR00566. | 0.900 |
| MCA1495 | ubiA | MCA1495 | MCA1336 | Conserved hypothetical protein; Identified by similarity to GP:2624947. | 4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate. | 0.902 |
| MCA1495 | ubiC | MCA1495 | MCA1335 | Conserved hypothetical protein; Identified by similarity to GP:2624947. | Putative chorismate--pyruvate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. | 0.904 |
| MCA2202 | MCA1495 | MCA2202 | MCA1495 | Aspartate aminotransferase; Identified by similarity to SP:P23034; match to protein family HMM PF00155. | Conserved hypothetical protein; Identified by similarity to GP:2624947. | 0.800 |
| MCA2202 | hisC-1 | MCA2202 | MCA1113 | Aspartate aminotransferase; Identified by similarity to SP:P23034; match to protein family HMM PF00155. | Histidinol-phosphate aminotransferase; Identified by similarity to SP:P45358; match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.902 |
| MCA2202 | hisC-2 | MCA2202 | MCA1417 | Aspartate aminotransferase; Identified by similarity to SP:P23034; match to protein family HMM PF00155. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.910 |
| MCA2202 | pheA | MCA2202 | MCA1418 | Aspartate aminotransferase; Identified by similarity to SP:P23034; match to protein family HMM PF00155. | Chorismate mutase/prephenate dehydratase; Identified by similarity to SP:P27603; match to protein family HMM PF00800; match to protein family HMM PF01817; match to protein family HMM PF01842; match to protein family HMM TIGR01807. | 0.992 |
| MCA2202 | ubiC | MCA2202 | MCA1335 | Aspartate aminotransferase; Identified by similarity to SP:P23034; match to protein family HMM PF00155. | Putative chorismate--pyruvate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family. | 0.800 |
| aroC | MCA1495 | MCA0702 | MCA1495 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Conserved hypothetical protein; Identified by similarity to GP:2624947. | 0.902 |
| aroC | hisC-1 | MCA0702 | MCA1113 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Histidinol-phosphate aminotransferase; Identified by similarity to SP:P45358; match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.595 |
| aroC | hisC-2 | MCA0702 | MCA1417 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Histidinol-phosphate aminotransferase; Identified by match to protein family HMM PF00155; match to protein family HMM TIGR01141; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.595 |
| aroC | pheA | MCA0702 | MCA1418 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Chorismate mutase/prephenate dehydratase; Identified by similarity to SP:P27603; match to protein family HMM PF00800; match to protein family HMM PF01817; match to protein family HMM PF01842; match to protein family HMM TIGR01807. | 0.987 |
| aroC | trpE | MCA0702 | MCA2584 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.946 |
| aroC | trpG | MCA0702 | MCA2585 | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | Anthranilate synthase component II; Identified by similarity to SP:P20576; match to protein family HMM PF00117; match to protein family HMM TIGR00566. | 0.958 |
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