Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
pqqECoenzyme PQQ synthesis protein E; Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ). (373 aa)    
Predicted Functional Partners:
pqqC
Coenzyme PQQ synthesis protein C; Ring cyclization and eight-electron oxidation of 3a-(2-amino- 2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline-7,9- dicarboxylic-acid to PQQ.
 
  
 0.982
pqqD
Coenzyme PQQ synthesis protein D; Functions as a PqqA binding protein and presents PqqA to PqqE, in the pyrroloquinoline quinone (PQQ) biosynthetic pathway.
 
  
 0.982
pqqB
Coenzyme PQQ synthesis protein B; May be involved in the transport of PQQ or its precursor to the periplasm, in association with PQQ biosynthesis, but is not absolutely required for this synthesis; Belongs to the PqqB family.
 
  
 0.981
MCA0299
Putative methanol dehydrogenase protein, large subunit; Identified by similarity to SP:P15279; match to protein family HMM PF01011.
  
  
 0.739
mxaF
Methanol dehydrogenase protein, large subunit; Identified by similarity to SP:P16027; match to protein family HMM PF01011.
  
  
 0.686
MCA1279
Conserved hypothetical protein; Identified by similarity to OMNI:NTL01SMB00179; match to protein family HMM TIGR02276.
 
  
 0.599
pqqA
Coenzyme PQQ biosynthesis protein A; Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis. PQQ is probably formed by cross-linking a specific glutamate to a specific tyrosine residue and excising these residues from the peptide; Belongs to the PqqA family.
       0.540
MCA0891
Conserved hypothetical protein; Identified by similarity to GP:18159248; match to protein family HMM PF04055.
  
     0.493
MCA2380
Conserved hypothetical protein; Identified by similarity to GP:19915811; match to protein family HMM PF00058; match to protein family HMM TIGR02276.
 
  
 0.444
MCA1280
ABC transporter, ATP-binding protein; Identified by similarity to OMNI:NTL01SMB00184; match to protein family HMM PF00005.
  
    0.409
Your Current Organism:
Methylococcus capsulatus
NCBI taxonomy Id: 243233
Other names: M. capsulatus str. Bath, Methylococcus capsulatus ATCC 33009, Methylococcus capsulatus Bath, Methylococcus capsulatus MC, Methylococcus capsulatus NCIB 11132, Methylococcus capsulatus str. Bath
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