Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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hypAHydrogenase expression/formation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (117 aa)    
Predicted Functional Partners:
hypB
Hydrogenase accessory protein HypB; Identified by similarity to SP:P24190; match to protein family HMM PF02492; match to protein family HMM TIGR00073.
 
 
 0.991
hypC
Hydrogenase assembly chaperone hypC/hupF; Identified by similarity to SP:P24191; match to protein family HMM PF01455; match to protein family HMM TIGR00074.
 
  
 0.963
hypF
[NiFe] hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
   
 0.956
hypD
Hydrogenase expression/formation protein HypD; Identified by match to protein family HMM PF01924; Belongs to the HypD family.
 
  
 0.948
MCA0165
Nickel-iron hydrogenase, large subunit; Identified by similarity to SP:P18636; match to protein family HMM PF00374; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.855
hypE
Hydrogenase expression/formation protein HypE; Identified by similarity to SP:P40595; match to protein family HMM PF02769; match to protein family HMM TIGR02124.
 
  
 0.852
MCA0162
Hydrogenase expression/formation protein; Identified by similarity to SP:Q03004; match to protein family HMM PF01750; match to protein family HMM TIGR00072; match to protein family HMM TIGR00140; match to protein family HMM TIGR00141.
  
  
 0.762
MCA1138
Hydrogenase subunit; Identified by similarity to SP:P77329; match to protein family HMM PF00329; match to protein family HMM PF00346.
  
 
 0.724
nuoA
NADH dehydrogenase I, A subunit; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; Belongs to the complex I subunit 3 family.
      
 0.647
ppa
Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
      
 0.645
Your Current Organism:
Methylococcus capsulatus
NCBI taxonomy Id: 243233
Other names: M. capsulatus str. Bath, Methylococcus capsulatus ATCC 33009, Methylococcus capsulatus Bath, Methylococcus capsulatus MC, Methylococcus capsulatus NCIB 11132, Methylococcus capsulatus str. Bath
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