Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
folEGTP cyclohydrolase I; Identified by similarity to SP:Q54769; match to protein family HMM PF01227; match to protein family HMM TIGR00063. (185 aa)    
Predicted Functional Partners:
MCA2527
Putative 6-pyruvoyl tetrahydropterin synthase; Identified by similarity to SP:Q46903; match to protein family HMM PF01242.
  
 
 0.975
folP
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
  
 0.964
folK-1
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Identified by similarity to SP:P26281; match to protein family HMM PF01288; match to protein family HMM TIGR01498.
 
  
 0.951
ribBA
3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family.
  
 
 0.950
folB
Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
 
  
 0.929
folE2
Conserved hypothetical protein; Converts GTP to 7,8-dihydroneopterin triphosphate.
     
 0.925
MCA0221
Conserved domain protein; Identified by similarity to GP:17135185.
    
 0.916
moaA
Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
    
 0.912
MCA2187
Identified by match to protein family HMM PF00245; Belongs to the alkaline phosphatase family.
     
  0.900
folK-2
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Identified by similarity to OMNI:NTL01EC00142; match to protein family HMM PF01288; match to protein family HMM TIGR01498.
 
  
 0.870
Your Current Organism:
Methylococcus capsulatus
NCBI taxonomy Id: 243233
Other names: M. capsulatus str. Bath, Methylococcus capsulatus ATCC 33009, Methylococcus capsulatus Bath, Methylococcus capsulatus MC, Methylococcus capsulatus NCIB 11132, Methylococcus capsulatus str. Bath
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