rfaE protein (Methylococcus capsulatus) - STRING interaction network

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rfaE

Lipopolysaccharide biosynthesis protein RfaE; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family. (473 aa)

Predicted Functional Partners:

gmhA

0.997

MCA2051

0.986

MCA2713

0.857

dnaB

0.771

alr

0.768

pip

0.563

lpxK

0.536

MCA0746

0.463

kdtA

0.445

kdsB

0.434

Your Current Organism:

Methylococcus capsulatus

NCBI taxonomy Id: 243233
Other names: M. capsulatus str. Bath, Methylococcus capsulatus ATCC 33009, Methylococcus capsulatus Bath, Methylococcus capsulatus MC, Methylococcus capsulatus NCIB 11132, Methylococcus capsulatus str. Bath

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCA0746	MCA2713	MCA0746	MCA2713	Sugar isomerase, KpsF/GutQ; Identified by similarity to SP:P45395; match to protein family HMM PF00571; match to protein family HMM PF01380; match to protein family HMM TIGR00393.	Putative lipopolysaccharide heptosyltransferase-1; Identified by similarity to SP:P24173; match to protein family HMM PF01075.	0.466
MCA0746	gmhA	MCA0746	MCA0183	Sugar isomerase, KpsF/GutQ; Identified by similarity to SP:P45395; match to protein family HMM PF00571; match to protein family HMM PF01380; match to protein family HMM TIGR00393.	Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.	0.480
MCA0746	kdsB	MCA0746	MCA0635	Sugar isomerase, KpsF/GutQ; Identified by similarity to SP:P45395; match to protein family HMM PF00571; match to protein family HMM PF01380; match to protein family HMM TIGR00393.	3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.	0.878
MCA0746	kdtA	MCA0746	MCA2034	Sugar isomerase, KpsF/GutQ; Identified by similarity to SP:P45395; match to protein family HMM PF00571; match to protein family HMM PF01380; match to protein family HMM TIGR00393.	3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.	0.870
MCA0746	lpxK	MCA0746	MCA0633	Sugar isomerase, KpsF/GutQ; Identified by similarity to SP:P45395; match to protein family HMM PF00571; match to protein family HMM PF01380; match to protein family HMM TIGR00393.	Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).	0.866
MCA0746	rfaE	MCA0746	MCA1736	Sugar isomerase, KpsF/GutQ; Identified by similarity to SP:P45395; match to protein family HMM PF00571; match to protein family HMM PF01380; match to protein family HMM TIGR00393.	Lipopolysaccharide biosynthesis protein RfaE; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family.	0.463
MCA2051	MCA2713	MCA2051	MCA2713	Hydrolase, HAD-superfamily, subfamily IIIA; Identified by match to protein family HMM TIGR01656; match to protein family HMM TIGR01662.	Putative lipopolysaccharide heptosyltransferase-1; Identified by similarity to SP:P24173; match to protein family HMM PF01075.	0.827
MCA2051	gmhA	MCA2051	MCA0183	Hydrolase, HAD-superfamily, subfamily IIIA; Identified by match to protein family HMM TIGR01656; match to protein family HMM TIGR01662.	Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.	0.996
MCA2051	rfaE	MCA2051	MCA1736	Hydrolase, HAD-superfamily, subfamily IIIA; Identified by match to protein family HMM TIGR01656; match to protein family HMM TIGR01662.	Lipopolysaccharide biosynthesis protein RfaE; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family.	0.986
MCA2713	MCA0746	MCA2713	MCA0746	Putative lipopolysaccharide heptosyltransferase-1; Identified by similarity to SP:P24173; match to protein family HMM PF01075.	Sugar isomerase, KpsF/GutQ; Identified by similarity to SP:P45395; match to protein family HMM PF00571; match to protein family HMM PF01380; match to protein family HMM TIGR00393.	0.466
MCA2713	MCA2051	MCA2713	MCA2051	Putative lipopolysaccharide heptosyltransferase-1; Identified by similarity to SP:P24173; match to protein family HMM PF01075.	Hydrolase, HAD-superfamily, subfamily IIIA; Identified by match to protein family HMM TIGR01656; match to protein family HMM TIGR01662.	0.827
MCA2713	gmhA	MCA2713	MCA0183	Putative lipopolysaccharide heptosyltransferase-1; Identified by similarity to SP:P24173; match to protein family HMM PF01075.	Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.	0.828
MCA2713	kdsB	MCA2713	MCA0635	Putative lipopolysaccharide heptosyltransferase-1; Identified by similarity to SP:P24173; match to protein family HMM PF01075.	3-deoxy-D-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.	0.519
MCA2713	kdtA	MCA2713	MCA2034	Putative lipopolysaccharide heptosyltransferase-1; Identified by similarity to SP:P24173; match to protein family HMM PF01075.	3-deoxy-D-manno-octulosonic-acid transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family.	0.934
MCA2713	lpxK	MCA2713	MCA0633	Putative lipopolysaccharide heptosyltransferase-1; Identified by similarity to SP:P24173; match to protein family HMM PF01075.	Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).	0.632
MCA2713	rfaE	MCA2713	MCA1736	Putative lipopolysaccharide heptosyltransferase-1; Identified by similarity to SP:P24173; match to protein family HMM PF01075.	Lipopolysaccharide biosynthesis protein RfaE; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family.	0.857
alr	dnaB	MCA1734	MCA1735	Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.	Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily.	0.856
alr	pip	MCA1734	MCA1737	Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.	Proline iminopeptidase; Identified by similarity to SP:P52279; match to protein family HMM PF00561; match to protein family HMM TIGR01249; Belongs to the peptidase S33 family.	0.602
alr	rfaE	MCA1734	MCA1736	Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.	Lipopolysaccharide biosynthesis protein RfaE; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the C-terminal section; belongs to the cytidylyltransferase family.	0.768
dnaB	alr	MCA1735	MCA1734	Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily.	Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.	0.856

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