| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MCA1034 | speD | MCA1034 | MCA1749 | Conserved hypothetical protein; Identified by similarity to OMNI:NMB0869; match to protein family HMM PF01564. | S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. | 0.979 |
| MCA1034 | speE | MCA1034 | MCA2046 | Conserved hypothetical protein; Identified by similarity to OMNI:NMB0869; match to protein family HMM PF01564. | Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine. | 0.936 |
| MCA1616 | metK-1 | MCA1616 | MCA0139 | C-5 cytosine-specific DNA methylase family protein; Identified by match to protein family HMM PF00145; match to protein family HMM TIGR00675. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.912 |
| MCA1616 | metK-2 | MCA1616 | MCA0450 | C-5 cytosine-specific DNA methylase family protein; Identified by match to protein family HMM PF00145; match to protein family HMM TIGR00675. | S-adenosylmethionine synthetase; Identified by match to protein family HMM PF00438; match to protein family HMM PF02772; match to protein family HMM PF02773; match to protein family HMM TIGR01034; Belongs to the AdoMet synthase family. | 0.912 |
| MCA1616 | speD | MCA1616 | MCA1749 | C-5 cytosine-specific DNA methylase family protein; Identified by match to protein family HMM PF00145; match to protein family HMM TIGR00675. | S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. | 0.900 |
| MCA1750 | speD | MCA1750 | MCA1749 | OsmC/Ohr family protein; Identified by similarity to OMNI:NTL03PA00654; match to protein family HMM PF02566. | S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. | 0.688 |
| metH | metK-1 | MCA1545 | MCA0139 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.956 |
| metH | metK-2 | MCA1545 | MCA0450 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosylmethionine synthetase; Identified by match to protein family HMM PF00438; match to protein family HMM PF02772; match to protein family HMM PF02773; match to protein family HMM TIGR01034; Belongs to the AdoMet synthase family. | 0.956 |
| metH | mtnA | MCA1545 | MCA1974 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Initiation factor 2 subunit family protein; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.783 |
| metH | mtnB | MCA1545 | MCA0799 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Conserved hypothetical protein; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. | 0.466 |
| metH | mtnD | MCA1545 | MCA0798 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Dioxygenase, ARD/ARD' family; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.634 |
| metH | speD | MCA1545 | MCA1749 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. | 0.477 |
| metK-1 | MCA1616 | MCA0139 | MCA1616 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | C-5 cytosine-specific DNA methylase family protein; Identified by match to protein family HMM PF00145; match to protein family HMM TIGR00675. | 0.912 |
| metK-1 | metH | MCA0139 | MCA1545 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.956 |
| metK-1 | metK-2 | MCA0139 | MCA0450 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | S-adenosylmethionine synthetase; Identified by match to protein family HMM PF00438; match to protein family HMM PF02772; match to protein family HMM PF02773; match to protein family HMM TIGR01034; Belongs to the AdoMet synthase family. | 0.917 |
| metK-1 | speD | MCA0139 | MCA1749 | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. | 0.926 |
| metK-2 | MCA1616 | MCA0450 | MCA1616 | S-adenosylmethionine synthetase; Identified by match to protein family HMM PF00438; match to protein family HMM PF02772; match to protein family HMM PF02773; match to protein family HMM TIGR01034; Belongs to the AdoMet synthase family. | C-5 cytosine-specific DNA methylase family protein; Identified by match to protein family HMM PF00145; match to protein family HMM TIGR00675. | 0.912 |
| metK-2 | metH | MCA0450 | MCA1545 | S-adenosylmethionine synthetase; Identified by match to protein family HMM PF00438; match to protein family HMM PF02772; match to protein family HMM PF02773; match to protein family HMM TIGR01034; Belongs to the AdoMet synthase family. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.956 |
| metK-2 | metK-1 | MCA0450 | MCA0139 | S-adenosylmethionine synthetase; Identified by match to protein family HMM PF00438; match to protein family HMM PF02772; match to protein family HMM PF02773; match to protein family HMM TIGR01034; Belongs to the AdoMet synthase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.917 |
| metK-2 | speD | MCA0450 | MCA1749 | S-adenosylmethionine synthetase; Identified by match to protein family HMM PF00438; match to protein family HMM PF02772; match to protein family HMM PF02773; match to protein family HMM TIGR01034; Belongs to the AdoMet synthase family. | S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. | 0.926 |
