| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MCA0831 | MCA1850 | MCA0831 | MCA1850 | Chemotaxis protein; Identified by similarity to SP:P18769; match to protein family HMM PF00072; match to protein family HMM PF01627; match to protein family HMM PF02518. | Conserved hypothetical protein TIGR00253; Identified by similarity to OMNI:VC0635; match to protein family HMM PF01985; match to protein family HMM TIGR00253. | 0.432 |
| MCA0831 | topA | MCA0831 | MCA2839 | Chemotaxis protein; Identified by similarity to SP:P18769; match to protein family HMM PF00072; match to protein family HMM PF01627; match to protein family HMM PF02518. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.413 |
| MCA1850 | MCA0831 | MCA1850 | MCA0831 | Conserved hypothetical protein TIGR00253; Identified by similarity to OMNI:VC0635; match to protein family HMM PF01985; match to protein family HMM TIGR00253. | Chemotaxis protein; Identified by similarity to SP:P18769; match to protein family HMM PF00072; match to protein family HMM PF01627; match to protein family HMM PF02518. | 0.432 |
| MCA1850 | aroE | MCA1850 | MCA2794 | Conserved hypothetical protein TIGR00253; Identified by similarity to OMNI:VC0635; match to protein family HMM PF01985; match to protein family HMM TIGR00253. | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.489 |
| MCA1850 | infA | MCA1850 | MCA1790 | Conserved hypothetical protein TIGR00253; Identified by similarity to OMNI:VC0635; match to protein family HMM PF01985; match to protein family HMM TIGR00253. | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. | 0.400 |
| MCA1850 | nadD | MCA1850 | MCA1879 | Conserved hypothetical protein TIGR00253; Identified by similarity to OMNI:VC0635; match to protein family HMM PF01985; match to protein family HMM TIGR00253. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.772 |
| MCA1850 | rrmJ | MCA1850 | MCA1849 | Conserved hypothetical protein TIGR00253; Identified by similarity to OMNI:VC0635; match to protein family HMM PF01985; match to protein family HMM TIGR00253. | Ribosomal RNA large subunit methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. | 0.630 |
| MCA1850 | rsfS | MCA1850 | MCA2027 | Conserved hypothetical protein TIGR00253; Identified by similarity to OMNI:VC0635; match to protein family HMM PF01985; match to protein family HMM TIGR00253. | Iojap-related protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.509 |
| MCA1850 | topA | MCA1850 | MCA2839 | Conserved hypothetical protein TIGR00253; Identified by similarity to OMNI:VC0635; match to protein family HMM PF01985; match to protein family HMM TIGR00253. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.493 |
| aroE | MCA1850 | MCA2794 | MCA1850 | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Conserved hypothetical protein TIGR00253; Identified by similarity to OMNI:VC0635; match to protein family HMM PF01985; match to protein family HMM TIGR00253. | 0.489 |
| aroE | nadD | MCA2794 | MCA1879 | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.742 |
| aroE | topA | MCA2794 | MCA2839 | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.477 |
| infA | MCA1850 | MCA1790 | MCA1850 | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. | Conserved hypothetical protein TIGR00253; Identified by similarity to OMNI:VC0635; match to protein family HMM PF01985; match to protein family HMM TIGR00253. | 0.400 |
| nadD | MCA1850 | MCA1879 | MCA1850 | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Conserved hypothetical protein TIGR00253; Identified by similarity to OMNI:VC0635; match to protein family HMM PF01985; match to protein family HMM TIGR00253. | 0.772 |
| nadD | aroE | MCA1879 | MCA2794 | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). | 0.742 |
| nadD | rsfS | MCA1879 | MCA2027 | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Iojap-related protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | 0.972 |
| rrmJ | MCA1850 | MCA1849 | MCA1850 | Ribosomal RNA large subunit methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. | Conserved hypothetical protein TIGR00253; Identified by similarity to OMNI:VC0635; match to protein family HMM PF01985; match to protein family HMM TIGR00253. | 0.630 |
| rsfS | MCA1850 | MCA2027 | MCA1850 | Iojap-related protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | Conserved hypothetical protein TIGR00253; Identified by similarity to OMNI:VC0635; match to protein family HMM PF01985; match to protein family HMM TIGR00253. | 0.509 |
| rsfS | nadD | MCA2027 | MCA1879 | Iojap-related protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. | Nicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.972 |
| topA | MCA0831 | MCA2839 | MCA0831 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | Chemotaxis protein; Identified by similarity to SP:P18769; match to protein family HMM PF00072; match to protein family HMM PF01627; match to protein family HMM PF02518. | 0.413 |