Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MCA2033Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Identified by match to protein family HMM PF00483; match to protein family HMM PF01050; match to protein family HMM PF07883; match to protein family HMM TIGR01479; Belongs to the mannose-6-phosphate isomerase type 2 family. (485 aa)    
Predicted Functional Partners:
MCA2782
Identified by similarity to GP:150994; match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880.
 
 0.991
gmd
GDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose.
 
 
 0.973
MCA0147
Putative polysaccharide biosythesis protein; Identified by similarity to GP:4972659; match to protein family HMM PF02397.
  
  
 0.967
pgi
Glucose-6-phosphate isomerase; Identified by similarity to SP:P11537; match to protein family HMM PF00342.
  
 
 0.960
MCA0661
ROK family protein; Identified by similarity to SP:P75959; match to protein family HMM PF00480.
    
 0.943
rfbA
Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family.
  
 
 0.937
galE-2
UDP-glucose 4-epimerase; Identified by similarity to SP:Q59083; match to protein family HMM PF01370; match to protein family HMM PF07993; match to protein family HMM TIGR01179; Belongs to the NAD(P)-dependent epimerase/dehydratase family.
 
 
 0.937
ugd
UDP-glucose 6-dehydrogenase; Identified by similarity to SP:O54068; match to protein family HMM PF00984; match to protein family HMM PF03720; match to protein family HMM PF03721.
  
 
 0.935
glmS
Glucosamine--fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
    
 0.925
pfp
Putative 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade [...]
    
 0.921
Your Current Organism:
Methylococcus capsulatus
NCBI taxonomy Id: 243233
Other names: M. capsulatus str. Bath, Methylococcus capsulatus ATCC 33009, Methylococcus capsulatus Bath, Methylococcus capsulatus MC, Methylococcus capsulatus NCIB 11132, Methylococcus capsulatus str. Bath
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