lexA protein (Methylococcus capsulatus) - STRING interaction network

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lexA

LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (202 aa)

Predicted Functional Partners:

recA

0.978

MCA2165

0.976

MCA2166

0.936

dnaE2

0.879

recN

0.766

hoxW

0.750

kdpE

0.644

rpoD

0.557

uvrA

0.495

MCA1204

0.486

Your Current Organism:

Methylococcus capsulatus

NCBI taxonomy Id: 243233
Other names: M. capsulatus str. Bath, Methylococcus capsulatus ATCC 33009, Methylococcus capsulatus Bath, Methylococcus capsulatus MC, Methylococcus capsulatus NCIB 11132, Methylococcus capsulatus str. Bath

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCA1204	kdpE	MCA1204	MCA2213	Sensory box histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00785; match to protein family HMM PF00989; match to protein family HMM PF01590; match to protein family HMM PF01627; match to protein family HMM PF02518; match to protein family HMM TIGR00229.	DNA binding response regulator KdpE; Identified by similarity to SP:P21866; match to protein family HMM PF00072; match to protein family HMM PF00486.	0.947
MCA1204	lexA	MCA1204	MCA2167	Sensory box histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00785; match to protein family HMM PF00989; match to protein family HMM PF01590; match to protein family HMM PF01627; match to protein family HMM PF02518; match to protein family HMM TIGR00229.	LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.	0.486
MCA1204	recA	MCA1204	MCA0387	Sensory box histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00785; match to protein family HMM PF00989; match to protein family HMM PF01590; match to protein family HMM PF01627; match to protein family HMM PF02518; match to protein family HMM TIGR00229.	recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.590
MCA1204	rpoD	MCA1204	MCA2994	Sensory box histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00785; match to protein family HMM PF00989; match to protein family HMM PF01590; match to protein family HMM PF01627; match to protein family HMM PF02518; match to protein family HMM TIGR00229.	RNA polymerase sigma-70 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.	0.540
MCA2165	MCA2166	MCA2165	MCA2166	Conserved hypothetical protein; Identified by similarity to OMNI:NTL03PA00671.	Conserved hypothetical protein; Identified by similarity to GP:9946550.	0.998
MCA2165	dnaE2	MCA2165	MCA2164	Conserved hypothetical protein; Identified by similarity to OMNI:NTL03PA00671.	Putative DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.	0.970
MCA2165	lexA	MCA2165	MCA2167	Conserved hypothetical protein; Identified by similarity to OMNI:NTL03PA00671.	LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.	0.976
MCA2165	recA	MCA2165	MCA0387	Conserved hypothetical protein; Identified by similarity to OMNI:NTL03PA00671.	recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.	0.798
MCA2165	recN	MCA2165	MCA1860	Conserved hypothetical protein; Identified by similarity to OMNI:NTL03PA00671.	DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.	0.517
MCA2166	MCA2165	MCA2166	MCA2165	Conserved hypothetical protein; Identified by similarity to GP:9946550.	Conserved hypothetical protein; Identified by similarity to OMNI:NTL03PA00671.	0.998
MCA2166	dnaE2	MCA2166	MCA2164	Conserved hypothetical protein; Identified by similarity to GP:9946550.	Putative DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.	0.981
MCA2166	lexA	MCA2166	MCA2167	Conserved hypothetical protein; Identified by similarity to GP:9946550.	LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.	0.936
dnaE2	MCA2165	MCA2164	MCA2165	Putative DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.	Conserved hypothetical protein; Identified by similarity to OMNI:NTL03PA00671.	0.970
dnaE2	MCA2166	MCA2164	MCA2166	Putative DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.	Conserved hypothetical protein; Identified by similarity to GP:9946550.	0.981
dnaE2	lexA	MCA2164	MCA2167	Putative DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase.	LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.	0.879
hoxW	lexA	MCA0113	MCA2167	HoxW protein; Identified by similarity to GP:1313919.	LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.	0.750
hoxW	rpoD	MCA0113	MCA2994	HoxW protein; Identified by similarity to GP:1313919.	RNA polymerase sigma-70 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.	0.616
kdpE	MCA1204	MCA2213	MCA1204	DNA binding response regulator KdpE; Identified by similarity to SP:P21866; match to protein family HMM PF00072; match to protein family HMM PF00486.	Sensory box histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00785; match to protein family HMM PF00989; match to protein family HMM PF01590; match to protein family HMM PF01627; match to protein family HMM PF02518; match to protein family HMM TIGR00229.	0.947
kdpE	lexA	MCA2213	MCA2167	DNA binding response regulator KdpE; Identified by similarity to SP:P21866; match to protein family HMM PF00072; match to protein family HMM PF00486.	LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.	0.644
lexA	MCA1204	MCA2167	MCA1204	LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.	Sensory box histidine kinase/response regulator; Identified by match to protein family HMM PF00072; match to protein family HMM PF00512; match to protein family HMM PF00785; match to protein family HMM PF00989; match to protein family HMM PF01590; match to protein family HMM PF01627; match to protein family HMM PF02518; match to protein family HMM TIGR00229.	0.486

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