| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MCA0769 | ilvA | MCA0769 | MCA0354 | Pyruvate ferredoxin/flavodoxin oxidoreductase family protein; Identified by similarity to SP:P52647; match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM PF02775; match to protein family HMM TIGR02176. | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.576 |
| MCA0769 | ilvB | MCA0769 | MCA2270 | Pyruvate ferredoxin/flavodoxin oxidoreductase family protein; Identified by similarity to SP:P52647; match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM PF02775; match to protein family HMM TIGR02176. | Acetolactate synthase, large subunit, biosynthetic type; Identified by similarity to SP:P00893; match to protein family HMM PF00205; match to protein family HMM PF02776; match to protein family HMM TIGR00118. | 0.955 |
| MCA0769 | ilvC | MCA0769 | MCA2272 | Pyruvate ferredoxin/flavodoxin oxidoreductase family protein; Identified by similarity to SP:P52647; match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM PF02775; match to protein family HMM TIGR02176. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.505 |
| MCA0769 | ilvD | MCA0769 | MCA2082 | Pyruvate ferredoxin/flavodoxin oxidoreductase family protein; Identified by similarity to SP:P52647; match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM PF02775; match to protein family HMM TIGR02176. | Dihydroxy-acid dehydratase; Identified by similarity to SP:P51785; match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. | 0.407 |
| MCA0769 | ilvK | MCA0769 | MCA1837 | Pyruvate ferredoxin/flavodoxin oxidoreductase family protein; Identified by similarity to SP:P52647; match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM PF02775; match to protein family HMM TIGR02176. | Acetolactate synthase; Identified by similarity to SP:Q04789; match to protein family HMM PF00205; match to protein family HMM PF02776; match to protein family HMM TIGR02418; Belongs to the TPP enzyme family. | 0.955 |
| MCA0769 | ilvN | MCA0769 | MCA2271 | Pyruvate ferredoxin/flavodoxin oxidoreductase family protein; Identified by similarity to SP:P52647; match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM PF02775; match to protein family HMM TIGR02176. | Acetolactate synthase, small subunit; Identified by similarity to SP:P00894; match to protein family HMM PF01842; match to protein family HMM TIGR00119. | 0.937 |
| MCA0769 | leuA | MCA0769 | MCA2275 | Pyruvate ferredoxin/flavodoxin oxidoreductase family protein; Identified by similarity to SP:P52647; match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM PF02775; match to protein family HMM TIGR02176. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.954 |
| MCA0769 | sfcA | MCA0769 | MCA1836 | Pyruvate ferredoxin/flavodoxin oxidoreductase family protein; Identified by similarity to SP:P52647; match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM PF02775; match to protein family HMM TIGR02176. | Malate oxidoreductase; Identified by similarity to SP:P26616; match to protein family HMM PF00390; match to protein family HMM PF03949. | 0.947 |
| budA | ilvB | MCA1838 | MCA2270 | Alpha-acetolactate decarboxylase; Converts acetolactate into acetoin. | Acetolactate synthase, large subunit, biosynthetic type; Identified by similarity to SP:P00893; match to protein family HMM PF00205; match to protein family HMM PF02776; match to protein family HMM TIGR00118. | 0.963 |
| budA | ilvK | MCA1838 | MCA1837 | Alpha-acetolactate decarboxylase; Converts acetolactate into acetoin. | Acetolactate synthase; Identified by similarity to SP:Q04789; match to protein family HMM PF00205; match to protein family HMM PF02776; match to protein family HMM TIGR02418; Belongs to the TPP enzyme family. | 0.996 |
| budA | ilvN | MCA1838 | MCA2271 | Alpha-acetolactate decarboxylase; Converts acetolactate into acetoin. | Acetolactate synthase, small subunit; Identified by similarity to SP:P00894; match to protein family HMM PF01842; match to protein family HMM TIGR00119. | 0.916 |
| budA | sfcA | MCA1838 | MCA1836 | Alpha-acetolactate decarboxylase; Converts acetolactate into acetoin. | Malate oxidoreductase; Identified by similarity to SP:P26616; match to protein family HMM PF00390; match to protein family HMM PF03949. | 0.773 |
| ilvA | MCA0769 | MCA0354 | MCA0769 | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Pyruvate ferredoxin/flavodoxin oxidoreductase family protein; Identified by similarity to SP:P52647; match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM PF02775; match to protein family HMM TIGR02176. | 0.576 |
| ilvA | ilvB | MCA0354 | MCA2270 | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Acetolactate synthase, large subunit, biosynthetic type; Identified by similarity to SP:P00893; match to protein family HMM PF00205; match to protein family HMM PF02776; match to protein family HMM TIGR00118. | 0.931 |
| ilvA | ilvC | MCA0354 | MCA2272 | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.656 |
| ilvA | ilvD | MCA0354 | MCA2082 | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Dihydroxy-acid dehydratase; Identified by similarity to SP:P51785; match to protein family HMM PF00920; match to protein family HMM TIGR00110; Belongs to the IlvD/Edd family. | 0.907 |
| ilvA | ilvK | MCA0354 | MCA1837 | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Acetolactate synthase; Identified by similarity to SP:Q04789; match to protein family HMM PF00205; match to protein family HMM PF02776; match to protein family HMM TIGR02418; Belongs to the TPP enzyme family. | 0.931 |
| ilvA | ilvN | MCA0354 | MCA2271 | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Acetolactate synthase, small subunit; Identified by similarity to SP:P00894; match to protein family HMM PF01842; match to protein family HMM TIGR00119. | 0.980 |
| ilvA | leuB | MCA0354 | MCA2063 | Threonine ammonia-lyase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.934 |
| ilvB | MCA0769 | MCA2270 | MCA0769 | Acetolactate synthase, large subunit, biosynthetic type; Identified by similarity to SP:P00893; match to protein family HMM PF00205; match to protein family HMM PF02776; match to protein family HMM TIGR00118. | Pyruvate ferredoxin/flavodoxin oxidoreductase family protein; Identified by similarity to SP:P52647; match to protein family HMM PF00037; match to protein family HMM PF01558; match to protein family HMM PF01855; match to protein family HMM PF02775; match to protein family HMM TIGR02176. | 0.955 |
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