| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MCA2288 | MCA2289 | MCA2288 | MCA2289 | Putative cobalamin biosynthetic protein CobC; Identified by similarity to SP:P21633. | Nitroreductase family protein; Identified by similarity to GP:17431084; match to protein family HMM PF00881; match to protein family HMM TIGR02476. | 0.697 |
| MCA2288 | cobA | MCA2288 | MCA2291 | Putative cobalamin biosynthetic protein CobC; Identified by similarity to SP:P21633. | cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.955 |
| MCA2288 | cobB | MCA2288 | MCA2290 | Putative cobalamin biosynthetic protein CobC; Identified by similarity to SP:P21633. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.757 |
| MCA2288 | cobQ | MCA2288 | MCA2304 | Putative cobalamin biosynthetic protein CobC; Identified by similarity to SP:P21633. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.997 |
| MCA2288 | cobT | MCA2288 | MCA0463 | Putative cobalamin biosynthetic protein CobC; Identified by similarity to SP:P21633. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.676 |
| MCA2288 | cobU | MCA2288 | MCA0462 | Putative cobalamin biosynthetic protein CobC; Identified by similarity to SP:P21633. | Bifunctional cobalamin biosynthesis protein CobU; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.977 |
| MCA2288 | cysG | MCA2288 | MCA2089 | Putative cobalamin biosynthetic protein CobC; Identified by similarity to SP:P21633. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.484 |
| MCA2289 | MCA2288 | MCA2289 | MCA2288 | Nitroreductase family protein; Identified by similarity to GP:17431084; match to protein family HMM PF00881; match to protein family HMM TIGR02476. | Putative cobalamin biosynthetic protein CobC; Identified by similarity to SP:P21633. | 0.697 |
| MCA2289 | MCA2292 | MCA2289 | MCA2292 | Nitroreductase family protein; Identified by similarity to GP:17431084; match to protein family HMM PF00881; match to protein family HMM TIGR02476. | Conserved hypothetical protein; Identified by similarity to GP:17427338. | 0.773 |
| MCA2289 | MCA2293 | MCA2289 | MCA2293 | Nitroreductase family protein; Identified by similarity to GP:17431084; match to protein family HMM PF00881; match to protein family HMM TIGR02476. | precorrin-3B C17-methyltransferase/conserved domain protein; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01466. | 0.746 |
| MCA2289 | birA | MCA2289 | MCA1781 | Nitroreductase family protein; Identified by similarity to GP:17431084; match to protein family HMM PF00881; match to protein family HMM TIGR02476. | birA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.686 |
| MCA2289 | cobA | MCA2289 | MCA2291 | Nitroreductase family protein; Identified by similarity to GP:17431084; match to protein family HMM PF00881; match to protein family HMM TIGR02476. | cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.886 |
| MCA2289 | cobB | MCA2289 | MCA2290 | Nitroreductase family protein; Identified by similarity to GP:17431084; match to protein family HMM PF00881; match to protein family HMM TIGR02476. | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. | 0.983 |
| MCA2289 | cobQ | MCA2289 | MCA2304 | Nitroreductase family protein; Identified by similarity to GP:17431084; match to protein family HMM PF00881; match to protein family HMM TIGR02476. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.842 |
| MCA2289 | cobT | MCA2289 | MCA0463 | Nitroreductase family protein; Identified by similarity to GP:17431084; match to protein family HMM PF00881; match to protein family HMM TIGR02476. | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). | 0.988 |
| MCA2289 | cobU | MCA2289 | MCA0462 | Nitroreductase family protein; Identified by similarity to GP:17431084; match to protein family HMM PF00881; match to protein family HMM TIGR02476. | Bifunctional cobalamin biosynthesis protein CobU; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. | 0.813 |
| MCA2289 | cysG | MCA2289 | MCA2089 | Nitroreductase family protein; Identified by similarity to GP:17431084; match to protein family HMM PF00881; match to protein family HMM TIGR02476. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.903 |
| MCA2292 | MCA2289 | MCA2292 | MCA2289 | Conserved hypothetical protein; Identified by similarity to GP:17427338. | Nitroreductase family protein; Identified by similarity to GP:17431084; match to protein family HMM PF00881; match to protein family HMM TIGR02476. | 0.773 |
| MCA2292 | MCA2293 | MCA2292 | MCA2293 | Conserved hypothetical protein; Identified by similarity to GP:17427338. | precorrin-3B C17-methyltransferase/conserved domain protein; Identified by match to protein family HMM PF00590; match to protein family HMM TIGR01466. | 0.711 |
| MCA2292 | cobA | MCA2292 | MCA2291 | Conserved hypothetical protein; Identified by similarity to GP:17427338. | cob(I)alamin adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. | 0.783 |
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