| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MCA0977 | amt-1 | MCA0977 | MCA0268 | Putative nitrogen regulatory protein P-II; Identified by match to protein family HMM PF00543. | Ammonium transporter; Identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836. | 0.527 |
| MCA0977 | amt-2 | MCA0977 | MCA0490 | Putative nitrogen regulatory protein P-II; Identified by match to protein family HMM PF00543. | Ammonium transporter; Identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836. | 0.527 |
| MCA0977 | amt-3 | MCA0977 | MCA2136 | Putative nitrogen regulatory protein P-II; Identified by match to protein family HMM PF00543. | Ammonium transporter; Identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836. | 0.527 |
| MCA0977 | glnA | MCA0977 | MCA1677 | Putative nitrogen regulatory protein P-II; Identified by match to protein family HMM PF00543. | Glutamine synthetase, type I; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. | 0.607 |
| MCA0977 | glnD | MCA0977 | MCA0565 | Putative nitrogen regulatory protein P-II; Identified by match to protein family HMM PF00543. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen fixation and metabolism. | 0.977 |
| MCA0977 | glnE | MCA0977 | MCA2345 | Putative nitrogen regulatory protein P-II; Identified by match to protein family HMM PF00543. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.659 |
| amt-1 | MCA0977 | MCA0268 | MCA0977 | Ammonium transporter; Identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836. | Putative nitrogen regulatory protein P-II; Identified by match to protein family HMM PF00543. | 0.527 |
| amt-1 | glnA | MCA0268 | MCA1677 | Ammonium transporter; Identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836. | Glutamine synthetase, type I; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. | 0.505 |
| amt-1 | glnD | MCA0268 | MCA0565 | Ammonium transporter; Identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen fixation and metabolism. | 0.671 |
| amt-1 | glnE | MCA0268 | MCA2345 | Ammonium transporter; Identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.663 |
| amt-1 | ntrC | MCA0268 | MCA2541 | Ammonium transporter; Identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836. | Nitrogen regulation protein NR(I); Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. | 0.630 |
| amt-2 | MCA0977 | MCA0490 | MCA0977 | Ammonium transporter; Identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836. | Putative nitrogen regulatory protein P-II; Identified by match to protein family HMM PF00543. | 0.527 |
| amt-2 | glnA | MCA0490 | MCA1677 | Ammonium transporter; Identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836. | Glutamine synthetase, type I; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. | 0.700 |
| amt-2 | glnD | MCA0490 | MCA0565 | Ammonium transporter; Identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen fixation and metabolism. | 0.671 |
| amt-2 | glnE | MCA0490 | MCA2345 | Ammonium transporter; Identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.663 |
| amt-2 | ntrC | MCA0490 | MCA2541 | Ammonium transporter; Identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836. | Nitrogen regulation protein NR(I); Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. | 0.630 |
| amt-3 | MCA0977 | MCA2136 | MCA0977 | Ammonium transporter; Identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836. | Putative nitrogen regulatory protein P-II; Identified by match to protein family HMM PF00543. | 0.527 |
| amt-3 | glnA | MCA2136 | MCA1677 | Ammonium transporter; Identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836. | Glutamine synthetase, type I; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. | 0.505 |
| amt-3 | glnD | MCA2136 | MCA0565 | Ammonium transporter; Identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836. | protein-P-II uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen fixation and metabolism. | 0.671 |
| amt-3 | glnE | MCA2136 | MCA2345 | Ammonium transporter; Identified by match to protein family HMM PF00909; match to protein family HMM TIGR00836. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.663 |
