| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MCA1039 | MCA2614 | MCA1039 | MCA2614 | fxsA protein; Identified by similarity to SP:P37147; match to protein family HMM PF04186. | Thioredoxin family protein; Identified by similarity to GP:17427791; match to protein family HMM PF00085; match to protein family HMM TIGR01068. | 0.692 |
| MCA1039 | hslU | MCA1039 | MCA2015 | fxsA protein; Identified by similarity to SP:P37147; match to protein family HMM PF04186. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.428 |
| MCA1039 | hslV | MCA1039 | MCA2014 | fxsA protein; Identified by similarity to SP:P37147; match to protein family HMM PF04186. | ATP-dependent protease HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.693 |
| MCA1387 | MCA2614 | MCA1387 | MCA2614 | Putative arsenate reductase; Identified by similarity to SP:P45947; match to protein family HMM PF01451; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | Thioredoxin family protein; Identified by similarity to GP:17427791; match to protein family HMM PF00085; match to protein family HMM TIGR01068. | 0.539 |
| MCA2614 | MCA1039 | MCA2614 | MCA1039 | Thioredoxin family protein; Identified by similarity to GP:17427791; match to protein family HMM PF00085; match to protein family HMM TIGR01068. | fxsA protein; Identified by similarity to SP:P37147; match to protein family HMM PF04186. | 0.692 |
| MCA2614 | MCA1387 | MCA2614 | MCA1387 | Thioredoxin family protein; Identified by similarity to GP:17427791; match to protein family HMM PF00085; match to protein family HMM TIGR01068. | Putative arsenate reductase; Identified by similarity to SP:P45947; match to protein family HMM PF01451; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. | 0.539 |
| MCA2614 | dnaJ | MCA2614 | MCA1855 | Thioredoxin family protein; Identified by similarity to GP:17427791; match to protein family HMM PF00085; match to protein family HMM TIGR01068. | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.733 |
| MCA2614 | grpE | MCA2614 | MCA1857 | Thioredoxin family protein; Identified by similarity to GP:17427791; match to protein family HMM PF00085; match to protein family HMM TIGR01068. | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.803 |
| MCA2614 | hslU | MCA2614 | MCA2015 | Thioredoxin family protein; Identified by similarity to GP:17427791; match to protein family HMM PF00085; match to protein family HMM TIGR01068. | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.832 |
| MCA2614 | hslV | MCA2614 | MCA2014 | Thioredoxin family protein; Identified by similarity to GP:17427791; match to protein family HMM PF00085; match to protein family HMM TIGR01068. | ATP-dependent protease HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.826 |
| MCA2614 | htpG | MCA2614 | MCA0848 | Thioredoxin family protein; Identified by similarity to GP:17427791; match to protein family HMM PF00085; match to protein family HMM TIGR01068. | Heat shock protein HtpG; Molecular chaperone. Has ATPase activity. | 0.740 |
| MCA2614 | htpX | MCA2614 | MCA1383 | Thioredoxin family protein; Identified by similarity to GP:17427791; match to protein family HMM PF00085; match to protein family HMM TIGR01068. | Heat shock protein HtpX; Identified by similarity to SP:P23894; match to protein family HMM PF01435; match to protein family HMM PF06509; Belongs to the peptidase M48B family. | 0.542 |
| MCA2614 | trxB | MCA2614 | MCA1694 | Thioredoxin family protein; Identified by similarity to GP:17427791; match to protein family HMM PF00085; match to protein family HMM TIGR01068. | Thioredoxin-disulfide reductase; Identified by similarity to SP:P09625; match to protein family HMM PF00070; match to protein family HMM PF07992; match to protein family HMM TIGR01292. | 0.879 |
| MCA2614 | vanX | MCA2614 | MCA2615 | Thioredoxin family protein; Identified by similarity to GP:17427791; match to protein family HMM PF00085; match to protein family HMM TIGR01068. | D-alanyl-D-alanine dipeptidase; Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. | 0.727 |
| dnaJ | MCA2614 | MCA1855 | MCA2614 | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | Thioredoxin family protein; Identified by similarity to GP:17427791; match to protein family HMM PF00085; match to protein family HMM TIGR01068. | 0.733 |
| dnaJ | grpE | MCA1855 | MCA1857 | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...] | 0.988 |
| dnaJ | hslU | MCA1855 | MCA2015 | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.880 |
| dnaJ | hslV | MCA1855 | MCA2014 | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | ATP-dependent protease HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.869 |
| dnaJ | htpG | MCA1855 | MCA0848 | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | Heat shock protein HtpG; Molecular chaperone. Has ATPase activity. | 0.965 |
| dnaJ | htpX | MCA1855 | MCA1383 | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | Heat shock protein HtpX; Identified by similarity to SP:P23894; match to protein family HMM PF01435; match to protein family HMM PF06509; Belongs to the peptidase M48B family. | 0.659 |
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