| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MCA0448 | MCA0827 | MCA0448 | MCA0827 | 5'-nucleotidase family protein; Identified by similarity to OMNI:DR0505; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family. | HD domain protein; Identified by similarity to GP:15980550; match to protein family HMM PF01966. | 0.923 |
| MCA0448 | MCA1322 | MCA0448 | MCA1322 | 5'-nucleotidase family protein; Identified by similarity to OMNI:DR0505; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family. | 5'-nucleotidase; Identified by similarity to GP:12659324; match to protein family HMM PF06189. | 0.900 |
| MCA0448 | MCA3023 | MCA0448 | MCA3023 | 5'-nucleotidase family protein; Identified by similarity to OMNI:DR0505; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family. | Ham1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.900 |
| MCA0448 | dut | MCA0448 | MCA2783 | 5'-nucleotidase family protein; Identified by similarity to OMNI:DR0505; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family. | Deoxyuridine 5'triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.900 |
| MCA0448 | surE | MCA0448 | MCA2418 | 5'-nucleotidase family protein; Identified by similarity to OMNI:DR0505; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family. | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.936 |
| MCA0448 | thyA | MCA0448 | MCA2728 | 5'-nucleotidase family protein; Identified by similarity to OMNI:DR0505; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.905 |
| MCA0448 | tmk | MCA0448 | MCA1996 | 5'-nucleotidase family protein; Identified by similarity to OMNI:DR0505; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.928 |
| MCA0827 | MCA0448 | MCA0827 | MCA0448 | HD domain protein; Identified by similarity to GP:15980550; match to protein family HMM PF01966. | 5'-nucleotidase family protein; Identified by similarity to OMNI:DR0505; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family. | 0.923 |
| MCA0827 | MCA1322 | MCA0827 | MCA1322 | HD domain protein; Identified by similarity to GP:15980550; match to protein family HMM PF01966. | 5'-nucleotidase; Identified by similarity to GP:12659324; match to protein family HMM PF06189. | 0.900 |
| MCA0827 | dut | MCA0827 | MCA2783 | HD domain protein; Identified by similarity to GP:15980550; match to protein family HMM PF01966. | Deoxyuridine 5'triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.909 |
| MCA0827 | surE | MCA0827 | MCA2418 | HD domain protein; Identified by similarity to GP:15980550; match to protein family HMM PF01966. | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.937 |
| MCA0827 | thyA | MCA0827 | MCA2728 | HD domain protein; Identified by similarity to GP:15980550; match to protein family HMM PF01966. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.900 |
| MCA0827 | tmk | MCA0827 | MCA1996 | HD domain protein; Identified by similarity to GP:15980550; match to protein family HMM PF01966. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.900 |
| MCA1322 | MCA0448 | MCA1322 | MCA0448 | 5'-nucleotidase; Identified by similarity to GP:12659324; match to protein family HMM PF06189. | 5'-nucleotidase family protein; Identified by similarity to OMNI:DR0505; match to protein family HMM PF00149; match to protein family HMM PF02872; Belongs to the 5'-nucleotidase family. | 0.900 |
| MCA1322 | MCA0827 | MCA1322 | MCA0827 | 5'-nucleotidase; Identified by similarity to GP:12659324; match to protein family HMM PF06189. | HD domain protein; Identified by similarity to GP:15980550; match to protein family HMM PF01966. | 0.900 |
| MCA1322 | MCA3023 | MCA1322 | MCA3023 | 5'-nucleotidase; Identified by similarity to GP:12659324; match to protein family HMM PF06189. | Ham1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.900 |
| MCA1322 | dut | MCA1322 | MCA2783 | 5'-nucleotidase; Identified by similarity to GP:12659324; match to protein family HMM PF06189. | Deoxyuridine 5'triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.900 |
| MCA1322 | surE | MCA1322 | MCA2418 | 5'-nucleotidase; Identified by similarity to GP:12659324; match to protein family HMM PF06189. | Acid phosphatase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.900 |
| MCA1322 | thyA | MCA1322 | MCA2728 | 5'-nucleotidase; Identified by similarity to GP:12659324; match to protein family HMM PF06189. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.900 |
| MCA1322 | tmk | MCA1322 | MCA1996 | 5'-nucleotidase; Identified by similarity to GP:12659324; match to protein family HMM PF06189. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.900 |
