Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
folBDihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (121 aa)    
Predicted Functional Partners:
folK-2
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Identified by similarity to OMNI:NTL01EC00142; match to protein family HMM PF01288; match to protein family HMM TIGR01498.
 
 
 0.997
folK-1
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Identified by similarity to SP:P26281; match to protein family HMM PF01288; match to protein family HMM TIGR01498.
 
 
 0.991
folP
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
 
 
 0.990
folE
GTP cyclohydrolase I; Identified by similarity to SP:Q54769; match to protein family HMM PF01227; match to protein family HMM TIGR00063.
 
  
 0.929
MCA0221
Conserved domain protein; Identified by similarity to GP:17135185.
     
 0.910
MCA2187
Identified by match to protein family HMM PF00245; Belongs to the alkaline phosphatase family.
     
 0.901
MCA1245
Pterin-binding domain protein; Identified by match to protein family HMM PF00809.
  
  
 0.785
folC
Folylpolyglutamate synthase/dihydrofolate synthase; Identified by similarity to SP:P08192; match to protein family HMM PF02875; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family.
  
  
 0.672
plsY
Conserved hypothetical protein TIGR00023; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.
  
    0.652
ribD
Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
  
 0.618
Your Current Organism:
Methylococcus capsulatus
NCBI taxonomy Id: 243233
Other names: M. capsulatus str. Bath, Methylococcus capsulatus ATCC 33009, Methylococcus capsulatus Bath, Methylococcus capsulatus MC, Methylococcus capsulatus NCIB 11132, Methylococcus capsulatus str. Bath
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