| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| birA | guaA | plu4732 | plu2712 | Bifunctional protein [Includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.715 |
| birA | plu0168 | plu4732 | plu0168 | Bifunctional protein [Includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Unnamed protein product; Similar to deoxycytidylate deaminase-related protein. | 0.560 |
| birA | plu1629 | plu4732 | plu1629 | Bifunctional protein [Includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Lactamase_B domain-containing protein; Unnamed protein product; Similar to probable membrane protein YcaI of Escherichia coli. | 0.592 |
| birA | ribD | plu4732 | plu3899 | Bifunctional protein [Includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.685 |
| guaA | birA | plu2712 | plu4732 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Bifunctional protein [Includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.715 |
| guaA | plu0168 | plu2712 | plu0168 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Unnamed protein product; Similar to deoxycytidylate deaminase-related protein. | 0.436 |
| guaA | polA | plu2712 | plu0386 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.778 |
| guaA | ribD | plu2712 | plu3899 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.690 |
| plu0168 | birA | plu0168 | plu4732 | Unnamed protein product; Similar to deoxycytidylate deaminase-related protein. | Bifunctional protein [Includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.560 |
| plu0168 | guaA | plu0168 | plu2712 | Unnamed protein product; Similar to deoxycytidylate deaminase-related protein. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.436 |
| plu0168 | plu0169 | plu0168 | plu0169 | Unnamed protein product; Similar to deoxycytidylate deaminase-related protein. | Unnamed protein product; Hypothetical gene. | 0.425 |
| plu0168 | plu1629 | plu0168 | plu1629 | Unnamed protein product; Similar to deoxycytidylate deaminase-related protein. | Lactamase_B domain-containing protein; Unnamed protein product; Similar to probable membrane protein YcaI of Escherichia coli. | 0.772 |
| plu0168 | polA | plu0168 | plu0386 | Unnamed protein product; Similar to deoxycytidylate deaminase-related protein. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.454 |
| plu0168 | ribD | plu0168 | plu3899 | Unnamed protein product; Similar to deoxycytidylate deaminase-related protein. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.479 |
| plu0169 | plu0168 | plu0169 | plu0168 | Unnamed protein product; Hypothetical gene. | Unnamed protein product; Similar to deoxycytidylate deaminase-related protein. | 0.425 |
| plu1629 | birA | plu1629 | plu4732 | Lactamase_B domain-containing protein; Unnamed protein product; Similar to probable membrane protein YcaI of Escherichia coli. | Bifunctional protein [Includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.592 |
| plu1629 | plu0168 | plu1629 | plu0168 | Lactamase_B domain-containing protein; Unnamed protein product; Similar to probable membrane protein YcaI of Escherichia coli. | Unnamed protein product; Similar to deoxycytidylate deaminase-related protein. | 0.772 |
| plu1629 | polA | plu1629 | plu0386 | Lactamase_B domain-containing protein; Unnamed protein product; Similar to probable membrane protein YcaI of Escherichia coli. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.434 |
| plu1629 | ribD | plu1629 | plu3899 | Lactamase_B domain-containing protein; Unnamed protein product; Similar to probable membrane protein YcaI of Escherichia coli. | Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.551 |
| polA | guaA | plu0386 | plu2712 | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.778 |