STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
gmkGuanylate kinase (GMP kinase); Essential for recycling GMP and indirectly, cGMP. (207 aa)    
Predicted Functional Partners:
spoT
GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
 0.970
rpoZ
DNA-directed RNA polymerase omega chain (transcriptase omega chain) (RNA polymerase omega subunit); Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.
  
  
 0.970
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.
 
 
 0.964
gpt
Xanthine-guanine phosphoribosyltransferase (XGPRT); Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily.
  
 
 0.950
apt
Adenine phosphoribosyltransferase (APRT); Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 
 0.950
pykF
Pyruvate kinase I (PK-1); Belongs to the pyruvate kinase family.
 
 
 0.929
plu0860
Unnamed protein product; Highly similar to hypoxanthine phosphoribosyltransferase of Escherichia coli; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
  
 0.927
plu0864
Unnamed protein product; Highly similar to hypoxanthine phosphoribosyltransferase of Escherichia coli; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
  
 0.927
pykA
Pyruvate kinase II; Belongs to the pyruvate kinase family.
 
 
 0.925
ndk
Nucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
   
 0.921
Your Current Organism:
Photorhabdus laumondii
NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1
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