| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| fre | hpaC | plu4404 | plu0974 | NAD(P)H-flavin reductase (NAD(P)H:flavin oxidoreductase). | 4-hydroxyphenylacetic acid hydroxylase. | 0.917 |
| fre | plu3812 | plu4404 | plu3812 | NAD(P)H-flavin reductase (NAD(P)H:flavin oxidoreductase). | Unnamed protein product; Weakly similar to riboflavin synthase, alpha chain RibE. | 0.901 |
| fre | plu4637 | plu4404 | plu4637 | NAD(P)H-flavin reductase (NAD(P)H:flavin oxidoreductase). | Unnamed protein product; Similar to unknown protein YigB of Escherichia coli. | 0.902 |
| fre | ribE | plu4404 | plu2610 | NAD(P)H-flavin reductase (NAD(P)H:flavin oxidoreductase). | Riboflavin synthase alpha chain. | 0.901 |
| fre | ribF | plu4404 | plu0590 | NAD(P)H-flavin reductase (NAD(P)H:flavin oxidoreductase). | Riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. | 0.907 |
| hpaC | fre | plu0974 | plu4404 | 4-hydroxyphenylacetic acid hydroxylase. | NAD(P)H-flavin reductase (NAD(P)H:flavin oxidoreductase). | 0.917 |
| hpaC | plu3812 | plu0974 | plu3812 | 4-hydroxyphenylacetic acid hydroxylase. | Unnamed protein product; Weakly similar to riboflavin synthase, alpha chain RibE. | 0.902 |
| hpaC | plu4637 | plu0974 | plu4637 | 4-hydroxyphenylacetic acid hydroxylase. | Unnamed protein product; Similar to unknown protein YigB of Escherichia coli. | 0.901 |
| hpaC | ribE | plu0974 | plu2610 | 4-hydroxyphenylacetic acid hydroxylase. | Riboflavin synthase alpha chain. | 0.902 |
| hpaC | ribF | plu0974 | plu0590 | 4-hydroxyphenylacetic acid hydroxylase. | Riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. | 0.907 |
| ileS | lspA | plu0591 | plu0592 | Isoleucine tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. | Lipoprotein signal peptidase (Prolipoprotein signal peptidase) (Signal peptidase II) (SPase II); This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | 0.898 |
| ileS | ribF | plu0591 | plu0590 | Isoleucine tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. | Riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. | 0.745 |
| lspA | ileS | plu0592 | plu0591 | Lipoprotein signal peptidase (Prolipoprotein signal peptidase) (Signal peptidase II) (SPase II); This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | Isoleucine tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. | 0.898 |
| lspA | mviN | plu0592 | plu2091 | Lipoprotein signal peptidase (Prolipoprotein signal peptidase) (Signal peptidase II) (SPase II); This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | Virulence factor MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. | 0.504 |
| lspA | ribF | plu0592 | plu0590 | Lipoprotein signal peptidase (Prolipoprotein signal peptidase) (Signal peptidase II) (SPase II); This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | Riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. | 0.814 |
| mssA | ribF | plu1621 | plu0590 | Cytidylate kinase (CK) (cytidine monophosphate kinase) (CMP kinase) (MssA protein) (P25). | Riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. | 0.762 |
| mviN | lspA | plu2091 | plu0592 | Virulence factor MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. | Lipoprotein signal peptidase (Prolipoprotein signal peptidase) (Signal peptidase II) (SPase II); This protein specifically catalyzes the removal of signal peptides from prolipoproteins; Belongs to the peptidase A8 family. | 0.504 |
| mviN | ribF | plu2091 | plu0590 | Virulence factor MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. | Riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. | 0.796 |
| plu3812 | fre | plu3812 | plu4404 | Unnamed protein product; Weakly similar to riboflavin synthase, alpha chain RibE. | NAD(P)H-flavin reductase (NAD(P)H:flavin oxidoreductase). | 0.901 |
| plu3812 | hpaC | plu3812 | plu0974 | Unnamed protein product; Weakly similar to riboflavin synthase, alpha chain RibE. | 4-hydroxyphenylacetic acid hydroxylase. | 0.902 |