node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cbiK | cbiL | plu2989 | plu2988 | Cobalt chelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. | Precorrin-2 C20-methyltransferase (S-adenosyl-L-methionine--precorrin-2 methyltransferase) (SP2MT); Belongs to the precorrin methyltransferase family. | 0.999 |
cbiK | cysG | plu2989 | plu0708 | Cobalt chelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.953 |
cbiK | plu2965 | plu2989 | plu2965 | Cobalt chelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. | Unnamed protein product; Highly similar to the N-terminal region of siroheme synthase activity. | 0.911 |
cbiK | plu2968 | plu2989 | plu2968 | Cobalt chelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. | TP_methylase domain-containing protein; Unnamed protein product; Highly similar to the C-terminal region of siroheme synthase activity; Belongs to the precorrin methyltransferase family. | 0.421 |
cbiL | cbiK | plu2988 | plu2989 | Precorrin-2 C20-methyltransferase (S-adenosyl-L-methionine--precorrin-2 methyltransferase) (SP2MT); Belongs to the precorrin methyltransferase family. | Cobalt chelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. | 0.999 |
cbiL | cysG | plu2988 | plu0708 | Precorrin-2 C20-methyltransferase (S-adenosyl-L-methionine--precorrin-2 methyltransferase) (SP2MT); Belongs to the precorrin methyltransferase family. | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.945 |
cbiL | plu2965 | plu2988 | plu2965 | Precorrin-2 C20-methyltransferase (S-adenosyl-L-methionine--precorrin-2 methyltransferase) (SP2MT); Belongs to the precorrin methyltransferase family. | Unnamed protein product; Highly similar to the N-terminal region of siroheme synthase activity. | 0.921 |
cbiL | plu2968 | plu2988 | plu2968 | Precorrin-2 C20-methyltransferase (S-adenosyl-L-methionine--precorrin-2 methyltransferase) (SP2MT); Belongs to the precorrin methyltransferase family. | TP_methylase domain-containing protein; Unnamed protein product; Highly similar to the C-terminal region of siroheme synthase activity; Belongs to the precorrin methyltransferase family. | 0.941 |
cysD | cysG | plu0709 | plu0708 | Sulfate adenylyltransferase subunit 2 (sulfate adenylate transferase) (SAT) (ATP-sulfurylase small subunit). | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.973 |
cysD | cysH | plu0709 | plu0705 | Sulfate adenylyltransferase subunit 2 (sulfate adenylate transferase) (SAT) (ATP-sulfurylase small subunit). | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.924 |
cysD | cysI | plu0709 | plu0704 | Sulfate adenylyltransferase subunit 2 (sulfate adenylate transferase) (SAT) (ATP-sulfurylase small subunit). | Sulfite reductase [NADPH] hemoprotein beta-component (SIR-HP); Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.908 |
cysD | plu2968 | plu0709 | plu2968 | Sulfate adenylyltransferase subunit 2 (sulfate adenylate transferase) (SAT) (ATP-sulfurylase small subunit). | TP_methylase domain-containing protein; Unnamed protein product; Highly similar to the C-terminal region of siroheme synthase activity; Belongs to the precorrin methyltransferase family. | 0.639 |
cysG | cbiK | plu0708 | plu2989 | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Cobalt chelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. | 0.953 |
cysG | cbiL | plu0708 | plu2988 | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Precorrin-2 C20-methyltransferase (S-adenosyl-L-methionine--precorrin-2 methyltransferase) (SP2MT); Belongs to the precorrin methyltransferase family. | 0.945 |
cysG | cysD | plu0708 | plu0709 | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Sulfate adenylyltransferase subunit 2 (sulfate adenylate transferase) (SAT) (ATP-sulfurylase small subunit). | 0.973 |
cysG | cysH | plu0708 | plu0705 | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.946 |
cysG | cysI | plu0708 | plu0704 | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Sulfite reductase [NADPH] hemoprotein beta-component (SIR-HP); Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. | 0.964 |
cysG | hemC | plu0708 | plu4644 | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.942 |
cysG | hemD | plu0708 | plu4645 | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.952 |
cysG | hemE | plu0708 | plu0489 | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.945 |