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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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cysGSirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. (470 aa)    
Predicted Functional Partners:
cysI
Sulfite reductase [NADPH] hemoprotein beta-component (SIR-HP); Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.969
hemD
Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
  
 
 0.969
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
    
 0.962
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.962
cysD
Sulfate adenylyltransferase subunit 2 (sulfate adenylate transferase) (SAT) (ATP-sulfurylase small subunit).
  
  
 0.961
cbiL
Precorrin-2 C20-methyltransferase (S-adenosyl-L-methionine--precorrin-2 methyltransferase) (SP2MT); Belongs to the precorrin methyltransferase family.
    
 0.955
cbiK
Cobalt chelatase; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family.
 
  
 0.955
plu2968
TP_methylase domain-containing protein; Unnamed protein product; Highly similar to the C-terminal region of siroheme synthase activity; Belongs to the precorrin methyltransferase family.
 
 
0.949
cysH
Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily.
 
  
 0.921
cysC
Adenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate.
  
  
 0.915
Your Current Organism:
Photorhabdus laumondii
NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1
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