node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cysG | hemA | plu0708 | plu2069 | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.689 |
cysG | hemB | plu0708 | plu4407 | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase) (ALAD) (ALADH); Belongs to the ALAD family. | 0.826 |
cysG | hemC | plu0708 | plu4644 | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.942 |
cysG | hemE | plu0708 | plu0489 | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.945 |
cysG | hemL | plu0708 | plu0902 | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.635 |
cysG | plu2968 | plu0708 | plu2968 | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | TP_methylase domain-containing protein; Unnamed protein product; Highly similar to the C-terminal region of siroheme synthase activity; Belongs to the precorrin methyltransferase family. | 0.949 |
hemA | cysG | plu2069 | plu0708 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.689 |
hemA | hemB | plu2069 | plu4407 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase) (ALAD) (ALADH); Belongs to the ALAD family. | 0.854 |
hemA | hemC | plu2069 | plu4644 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.980 |
hemA | hemE | plu2069 | plu0489 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.623 |
hemA | hemL | plu2069 | plu0902 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.987 |
hemA | plu2968 | plu2069 | plu2968 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | TP_methylase domain-containing protein; Unnamed protein product; Highly similar to the C-terminal region of siroheme synthase activity; Belongs to the precorrin methyltransferase family. | 0.716 |
hemB | cysG | plu4407 | plu0708 | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase) (ALAD) (ALADH); Belongs to the ALAD family. | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.826 |
hemB | hemA | plu4407 | plu2069 | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase) (ALAD) (ALADH); Belongs to the ALAD family. | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.854 |
hemB | hemC | plu4407 | plu4644 | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase) (ALAD) (ALADH); Belongs to the ALAD family. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.994 |
hemB | hemE | plu4407 | plu0489 | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase) (ALAD) (ALADH); Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.741 |
hemB | hemL | plu4407 | plu0902 | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase) (ALAD) (ALADH); Belongs to the ALAD family. | Glutamate-1-semialdehyde 2,1-aminomutase. | 0.991 |
hemB | plu2968 | plu4407 | plu2968 | Delta-aminolevulinic acid dehydratase (porphobilinogen synthase) (ALAD) (ALADH); Belongs to the ALAD family. | TP_methylase domain-containing protein; Unnamed protein product; Highly similar to the C-terminal region of siroheme synthase activity; Belongs to the precorrin methyltransferase family. | 0.835 |
hemC | cysG | plu4644 | plu0708 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.942 |
hemC | hemA | plu4644 | plu2069 | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.980 |