| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| hpaA | hpaG1 | plu0980 | plu0990 | Regulator of the 4HPA-hydroxylase operon. | HpaG1 protein; Similar to N-terminal region of 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase HpaG [Includes: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase); 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase (OPET decarboxylase)]. | 0.682 |
| hpaA | hpaG2 | plu0980 | plu0989 | Regulator of the 4HPA-hydroxylase operon. | HpaG2 protein; Similar to C-terminal region of 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase HpaG [Includes: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase); 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase (OPET decarboxylase)]. | 0.675 |
| hpaA | hpaI | plu0980 | plu0982 | Regulator of the 4HPA-hydroxylase operon. | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Belongs to the HpcH/HpaI aldolase family. | 0.805 |
| hpaA | hpcB | plu0980 | plu0987 | Regulator of the 4HPA-hydroxylase operon. | 3,4-dihydroxyphenylacetate 2,3-dioxygenase. | 0.938 |
| hpaA | hpcC | plu0980 | plu0988 | Regulator of the 4HPA-hydroxylase operon. | 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.559 |
| hpaA | hpcD | plu0980 | plu0986 | Regulator of the 4HPA-hydroxylase operon. | 5-carboxymethyl-2-hydroxy-muconic acid isomerase. | 0.931 |
| hpaA | hpcG | plu0980 | plu0983 | Regulator of the 4HPA-hydroxylase operon. | 2-oxo-hepta-3-ene-1,7-dioic acid hydratase. | 0.792 |
| hpaB | hpcB | plu0975 | plu0987 | 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component (4-HPA 3-monooxygenase large component) (4-HPA 3-hydroxylase). | 3,4-dihydroxyphenylacetate 2,3-dioxygenase. | 0.919 |
| hpaB | hpcD | plu0975 | plu0986 | 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component (4-HPA 3-monooxygenase large component) (4-HPA 3-hydroxylase). | 5-carboxymethyl-2-hydroxy-muconic acid isomerase. | 0.439 |
| hpaB | hpcG | plu0975 | plu0983 | 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component (4-HPA 3-monooxygenase large component) (4-HPA 3-hydroxylase). | 2-oxo-hepta-3-ene-1,7-dioic acid hydratase. | 0.441 |
| hpaG1 | hpaA | plu0990 | plu0980 | HpaG1 protein; Similar to N-terminal region of 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase HpaG [Includes: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase); 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase (OPET decarboxylase)]. | Regulator of the 4HPA-hydroxylase operon. | 0.682 |
| hpaG1 | hpaG2 | plu0990 | plu0989 | HpaG1 protein; Similar to N-terminal region of 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase HpaG [Includes: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase); 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase (OPET decarboxylase)]. | HpaG2 protein; Similar to C-terminal region of 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase HpaG [Includes: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase); 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase (OPET decarboxylase)]. | 0.982 |
| hpaG1 | hpaI | plu0990 | plu0982 | HpaG1 protein; Similar to N-terminal region of 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase HpaG [Includes: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase); 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase (OPET decarboxylase)]. | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Belongs to the HpcH/HpaI aldolase family. | 0.776 |
| hpaG1 | hpcB | plu0990 | plu0987 | HpaG1 protein; Similar to N-terminal region of 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase HpaG [Includes: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase); 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase (OPET decarboxylase)]. | 3,4-dihydroxyphenylacetate 2,3-dioxygenase. | 0.905 |
| hpaG1 | hpcC | plu0990 | plu0988 | HpaG1 protein; Similar to N-terminal region of 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase HpaG [Includes: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase); 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase (OPET decarboxylase)]. | 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.857 |
| hpaG1 | hpcD | plu0990 | plu0986 | HpaG1 protein; Similar to N-terminal region of 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase HpaG [Includes: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase); 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase (OPET decarboxylase)]. | 5-carboxymethyl-2-hydroxy-muconic acid isomerase. | 0.990 |
| hpaG1 | hpcG | plu0990 | plu0983 | HpaG1 protein; Similar to N-terminal region of 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase HpaG [Includes: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase); 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase (OPET decarboxylase)]. | 2-oxo-hepta-3-ene-1,7-dioic acid hydratase. | 0.976 |
| hpaG2 | hpaA | plu0989 | plu0980 | HpaG2 protein; Similar to C-terminal region of 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase HpaG [Includes: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase); 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase (OPET decarboxylase)]. | Regulator of the 4HPA-hydroxylase operon. | 0.675 |
| hpaG2 | hpaG1 | plu0989 | plu0990 | HpaG2 protein; Similar to C-terminal region of 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase HpaG [Includes: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase); 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase (OPET decarboxylase)]. | HpaG1 protein; Similar to N-terminal region of 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase HpaG [Includes: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase); 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase (OPET decarboxylase)]. | 0.982 |
| hpaG2 | hpaI | plu0989 | plu0982 | HpaG2 protein; Similar to C-terminal region of 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase HpaG [Includes: 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase (HHDD isomerase); 5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase (OPET decarboxylase)]. | 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase; Belongs to the HpcH/HpaI aldolase family. | 0.779 |