Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
gshAGlutamate--cysteine ligase (Gamma-glutamylcysteine synthetase) (Gamma-ECS) (GCS); Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (519 aa)    
Predicted Functional Partners:
pepN
Aminopeptidase N.
     
 0.960
gshB
Glutathione synthase (glutathione synthase) (GSH synthetase) (GSH-S).
 
 
 0.959
pepA
Cytosol aminopeptidase (leucine aminopeptidase) (LAP) (leucyl aminopeptidase) (aminopeptidase A/I); Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.
     
 0.923
ggt
Gamma-glutamyltranspeptidase.
    
 0.918
pepD
Aminoacyl-histidine dipeptidase (XAA-His dipeptidase) (beta-alanyl-histidine dipeptidase) (carnosinase) (peptidase D).
     
 0.909
luxS
Autoinducer-2 (AI-2) production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
     
 0.908
pepB
Peptidase B (Aminopeptidase B); Probably plays an important role in intracellular peptide degradation.
     
 0.907
aspC
Aspartate aminotransferase (transaminase A).
     
 0.902
plu1438
Unnamed protein product; Similar to branched-chain amino acid aminotransferases.
     
  0.900
ilvE-2
Branched-chain-amino-acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
     
  0.900
Your Current Organism:
Photorhabdus laumondii
NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1
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