Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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Score
hemFOxygen-dependent coproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (302 aa)    
Predicted Functional Partners:
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.972
hemN
Oxygen-independent coproporphyrinogen III oxidase (coproporphyrinogenase) (coprogen oxidase); Belongs to the anaerobic coproporphyrinogen-III oxidase family.
    
 0.961
hemG
Protoporphyrinogen oxidase (PPO).
     
 0.945
hemH
Ferrochelatase (protoheme ferro-lyase) (heme synthetase); Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.708
hemY
HemY protein; Involved in a late step of protoheme IX synthesis.
    
 0.685
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 
 
 0.682
hemB
Delta-aminolevulinic acid dehydratase (porphobilinogen synthase) (ALAD) (ALADH); Belongs to the ALAD family.
 
 
 0.670
ubiF
2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase UbiF.
  
  
 0.580
visC
Probable monooxygenase VisC.
  
  
 0.569
ubiH
2-octaprenyl-6-methoxyphenol hydroxylase.
  
  
 0.554
Your Current Organism:
Photorhabdus laumondii
NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1
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