| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cysZ | ligA | plu1396 | plu1398 | Sulfate transport protein CysZ; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. | DNA ligase (polydeoxyribonucleotide synthase [NAD+]); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.487 |
| cysZ | zipA | plu1396 | plu1397 | Sulfate transport protein CysZ; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. | Cell division protein ZipA; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. | 0.638 |
| leuS | ligA | plu1303 | plu1398 | leucine-tRNA synthetase (leucine--tRNA ligase) (LEURS); Belongs to the class-I aminoacyl-tRNA synthetase family. | DNA ligase (polydeoxyribonucleotide synthase [NAD+]); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.672 |
| leuS | ligB | plu1303 | plu0286 | leucine-tRNA synthetase (leucine--tRNA ligase) (LEURS); Belongs to the class-I aminoacyl-tRNA synthetase family. | DNA ligase B; Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. Belongs to the NAD-dependent DNA ligase family. LigB subfamily. | 0.505 |
| leuS | plu1037 | plu1303 | plu1037 | leucine-tRNA synthetase (leucine--tRNA ligase) (LEURS); Belongs to the class-I aminoacyl-tRNA synthetase family. | Toprim domain-containing protein; Unnamed protein product; Similar to DNA topoisomerase III. | 0.893 |
| leuS | polA | plu1303 | plu0386 | leucine-tRNA synthetase (leucine--tRNA ligase) (LEURS); Belongs to the class-I aminoacyl-tRNA synthetase family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.486 |
| leuS | topA | plu1303 | plu2435 | leucine-tRNA synthetase (leucine--tRNA ligase) (LEURS); Belongs to the class-I aminoacyl-tRNA synthetase family. | DNA topoisomerase I (omega protein) (relaxing enzyme) (untwisting enzyme) (swivelase); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then un [...] | 0.893 |
| ligA | cysZ | plu1398 | plu1396 | DNA ligase (polydeoxyribonucleotide synthase [NAD+]); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | Sulfate transport protein CysZ; High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway; Belongs to the CysZ family. | 0.487 |
| ligA | leuS | plu1398 | plu1303 | DNA ligase (polydeoxyribonucleotide synthase [NAD+]); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | leucine-tRNA synthetase (leucine--tRNA ligase) (LEURS); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.672 |
| ligA | ligB | plu1398 | plu0286 | DNA ligase (polydeoxyribonucleotide synthase [NAD+]); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | DNA ligase B; Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. Belongs to the NAD-dependent DNA ligase family. LigB subfamily. | 0.925 |
| ligA | plu1037 | plu1398 | plu1037 | DNA ligase (polydeoxyribonucleotide synthase [NAD+]); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | Toprim domain-containing protein; Unnamed protein product; Similar to DNA topoisomerase III. | 0.534 |
| ligA | polA | plu1398 | plu0386 | DNA ligase (polydeoxyribonucleotide synthase [NAD+]); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.614 |
| ligA | rep | plu1398 | plu4667 | DNA ligase (polydeoxyribonucleotide synthase [NAD+]); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | ATP-dependent DNA helicase; Rep helicase is a single-stranded DNA-dependent ATPase involved in DNA replication; it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction. | 0.524 |
| ligA | rsmB | plu1398 | plu4697 | DNA ligase (polydeoxyribonucleotide synthase [NAD+]); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | RsmB protein (SUN/FMU protein), 16S RNA m5C967 methyltransferase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.549 |
| ligA | topA | plu1398 | plu2435 | DNA ligase (polydeoxyribonucleotide synthase [NAD+]); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | DNA topoisomerase I (omega protein) (relaxing enzyme) (untwisting enzyme) (swivelase); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then un [...] | 0.600 |
| ligA | uvrD | plu1398 | plu4636 | DNA ligase (polydeoxyribonucleotide synthase [NAD+]); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | DNA helicase II. | 0.548 |
| ligA | zipA | plu1398 | plu1397 | DNA ligase (polydeoxyribonucleotide synthase [NAD+]); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | Cell division protein ZipA; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. | 0.721 |
| ligB | leuS | plu0286 | plu1303 | DNA ligase B; Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. Belongs to the NAD-dependent DNA ligase family. LigB subfamily. | leucine-tRNA synthetase (leucine--tRNA ligase) (LEURS); Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.505 |
| ligB | ligA | plu0286 | plu1398 | DNA ligase B; Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. Belongs to the NAD-dependent DNA ligase family. LigB subfamily. | DNA ligase (polydeoxyribonucleotide synthase [NAD+]); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.925 |
| ligB | plu1037 | plu0286 | plu1037 | DNA ligase B; Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. Belongs to the NAD-dependent DNA ligase family. LigB subfamily. | Toprim domain-containing protein; Unnamed protein product; Similar to DNA topoisomerase III. | 0.534 |
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