Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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hisBHistidinol-phosphatase/imisazoleglycerol- phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (355 aa)    
Predicted Functional Partners:
hisI
phosphoribosyl-AMP cyclohydrolase (PRA-CH) / phosphoribosyl-ATP pyrophosphatase (PRA-PH); In the C-terminal section; belongs to the PRA-PH family.
 
  
 0.999
hisF
Imidazole glycerol phosphate synthase subunit HisF (IGP synthase cyclase subunit); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 
 
 0.999
hisH
Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.
 
 
 0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
 
 0.999
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
 
  
 0.999
plu1443
Aminotran_1_2 domain-containing protein; Unnamed protein product; Similar to histidinol-phosphate aminotransferase.
 
 0.998
hisA
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
 
  
 0.997
hisA2
Unnamed protein product; Similar to phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase.
 
  
 0.988
plu1412
Aminotransferase; Unnamed protein product; Similar to hemolysin erythrocyte lysis protein 2.
 
  
 0.969
cobD
Aminotransferase CobD.
  
 0.952
Your Current Organism:
Photorhabdus laumondii
NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1
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